P. Bialasiewicz , R. Stolarek , P. Wejner , G. Piasecka , B. Dutkiewicz , J. Mikucki , D. Nowak
{"title":"头孢地辛增强金黄色葡萄球菌的吞噬和细胞内杀伤，但不影响多形核白细胞对fMLP刺激的反应","authors":"P. Bialasiewicz , R. Stolarek , P. Wejner , G. Piasecka , B. Dutkiewicz , J. Mikucki , D. Nowak","doi":"10.1016/S0192-0561(00)00019-9","DOIUrl":null,"url":null,"abstract":"<div><p><span>The influence of Cefodizime<span><span><span> (CDZ) on in vitro activity of polymorphonuclear leukocytes (PMNL) from healthy subjects was assessed. Preincubation with CDZ enhanced </span>phagocytosis and </span>intracellular killing of </span></span><span><em>Staphylococcus aureus</em></span> by PMNL. Contrary to numerous clinical reports, no significant effect of CDZ preincubation on PMNL response to <em>n</em><span><span>-formyl-methionyl-leucyl-phenylalanine was found with respect to intracellular calcium<span> changes, degranulation, hydrogen peroxide production, and </span></span>chemiluminescence<span>. These results suggest that augmented microbicidal activity of PMNL is not related to the enhanced production of reactive oxygen species in healthy subjects.</span></span></p></div>","PeriodicalId":14002,"journal":{"name":"International journal of immunopharmacology","volume":"22 7","pages":"Pages 557-566"},"PeriodicalIF":0.0000,"publicationDate":"2000-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0192-0561(00)00019-9","citationCount":"4","resultStr":"{\"title\":\"Cefodizime enhances phagocytosis and intracellular killing of Staphylococcus aureus but does not influence polymorphonuclear leukocytes response to fMLP stimulation\",\"authors\":\"P. Bialasiewicz , R. Stolarek , P. Wejner , G. Piasecka , B. Dutkiewicz , J. Mikucki , D. Nowak\",\"doi\":\"10.1016/S0192-0561(00)00019-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>The influence of Cefodizime<span><span><span> (CDZ) on in vitro activity of polymorphonuclear leukocytes (PMNL) from healthy subjects was assessed. Preincubation with CDZ enhanced </span>phagocytosis and </span>intracellular killing of </span></span><span><em>Staphylococcus aureus</em></span> by PMNL. Contrary to numerous clinical reports, no significant effect of CDZ preincubation on PMNL response to <em>n</em><span><span>-formyl-methionyl-leucyl-phenylalanine was found with respect to intracellular calcium<span> changes, degranulation, hydrogen peroxide production, and </span></span>chemiluminescence<span>. These results suggest that augmented microbicidal activity of PMNL is not related to the enhanced production of reactive oxygen species in healthy subjects.</span></span></p></div>\",\"PeriodicalId\":14002,\"journal\":{\"name\":\"International journal of immunopharmacology\",\"volume\":\"22 7\",\"pages\":\"Pages 557-566\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0192-0561(00)00019-9\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of immunopharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0192056100000199\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of immunopharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0192056100000199","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Cefodizime enhances phagocytosis and intracellular killing of Staphylococcus aureus but does not influence polymorphonuclear leukocytes response to fMLP stimulation
The influence of Cefodizime (CDZ) on in vitro activity of polymorphonuclear leukocytes (PMNL) from healthy subjects was assessed. Preincubation with CDZ enhanced phagocytosis and intracellular killing of Staphylococcus aureus by PMNL. Contrary to numerous clinical reports, no significant effect of CDZ preincubation on PMNL response to n-formyl-methionyl-leucyl-phenylalanine was found with respect to intracellular calcium changes, degranulation, hydrogen peroxide production, and chemiluminescence. These results suggest that augmented microbicidal activity of PMNL is not related to the enhanced production of reactive oxygen species in healthy subjects.
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