喉癌治疗后的生活质量:手术与放疗。

A Schneider, M Guidicelli, S J Stöckli
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引用次数: 0

摘要

放疗和手术治疗喉癌的患者生存率相当。因此,预期的生活质量越来越影响治疗的选择。本研究的目的是比较喉癌手术或放疗后患者的生活质量。为了评估生活质量,我们使用了经过验证的欧洲癌症研究与治疗组织生活质量问卷核心30 (EORTC QLQ-C30)和EORTC头颈部模块(EORTC QLQ-H&N35)。在1990年1月至1995年12月期间,65名喉癌患者接受了放疗或手术治疗,并且在1999年1月还活着并且没有肿瘤,他们被纳入了这项研究。在第一组小肿瘤(T1/T2)中,40例患者接受co2激光手术治疗,16例接受原发性放疗。第二组肿瘤较晚期(T3/T4), 5例患者行全喉切除术,4例患者行原发性放疗。第一组患者总体生活质量良好,两种治疗方式之间无显著差异。手术治疗的患者在吞咽固体食物、口干和牙齿问题上的得分明显好于放射治疗的患者。没有发现其他显著差异:特别是在两种治疗后,声音嘶哑的评分是一样的。在第二组中,两种治疗方式之间没有显着差异,总体生活质量也很好。切除喉头的患者在语音功能、打电话和社交行为方面得分相同。就生活质量而言,我们可以为所有阶段的喉癌患者推荐两种治疗方式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Quality of life after treatment of laryngeal carcinoma: surgery versus radiotherapy].

Radiotherapy and surgery for laryngeal cancer achieve comparable results in patient survival. Therefore, the expected quality of life is increasingly influencing the choice of treatment. The aim of this study was to compare the quality of life of patients after surgery or radiotherapy for laryngeal carcinoma. To evaluate quality of life, we used the validated European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and the EORTC Head and Neck module (EORTC QLQ-H&N35). 65 patients who were treated with either radiotherapy or surgery for laryngeal cancer between January 1990 and December 1995, and who were alive and free of tumour in January 1999, were included in this study. In the first group with small tumours (T1/T2), 40 patients were treated by CO2-laser surgery and 16 by primary radiotherapy. In the second group with more advanced tumours (T3/T4), 5 patients underwent total laryngectomy and 4 primary radiotherapy. In the first group there was good global quality of life with no significant difference between the two treatment modalities. Surgically treated patients scored significantly better than the irradiated patients in questions about swallowing of solid food, xerostomia and dental problems. No other significant differences were found: hoarseness in particular was rated equally after both treatments. In the second group there was also good global quality of life with no significant difference between the two treatment modalities. The laryngectomized patients scored equally on questions about voice function, talking on the phone and social behaviour. As far as quality of life is concerned we can recommend both treatment modalities for patients with laryngeal cancer of all stages.

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