手性1,2-二胺催化-卤代醇的高效动力学拆分。

Enantiomer Pub Date : 2000-01-01

T Sano, H Miyata, T Oriyama

{"title":"手性1,2-二胺催化-卤代醇的高效动力学拆分。","authors":"T Sano, H Miyata, T Oriyama","doi":"","DOIUrl":null,"url":null,"abstract":"Kinetic resolution of racemic beta-halohydrins has been achieved by reaction with benzoyl chloride in the presence of a catalytic amount (0.3 mol%) of a chiral diamine combined with diisopropylethylamine to afford the corresponding benzoates and unreacted beta-halohydrins in good to excellent enantioselectivities. The benzoate can be converted to the corresponding allylic benzoate without loss of optical purity by treatment with (1,5-diazabicyclo[4.3.0]non-5-ene).","PeriodicalId":11752,"journal":{"name":"Enantiomer","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Highly efficient kinetic resolution of beta-halohydrins catalyzed by a chiral 1,2-diamine.\",\"authors\":\"T Sano, H Miyata, T Oriyama\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Kinetic resolution of racemic beta-halohydrins has been achieved by reaction with benzoyl chloride in the presence of a catalytic amount (0.3 mol%) of a chiral diamine combined with diisopropylethylamine to afford the corresponding benzoates and unreacted beta-halohydrins in good to excellent enantioselectivities. The benzoate can be converted to the corresponding allylic benzoate without loss of optical purity by treatment with (1,5-diazabicyclo[4.3.0]non-5-ene).\",\"PeriodicalId\":11752,\"journal\":{\"name\":\"Enantiomer\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Enantiomer\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Enantiomer","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

在手性二胺与二异丙基乙胺的催化量(0.3 mol%)存在下，通过与苯甲酰氯反应，实现了外消旋β -卤代醇的动力学拆分，得到相应的苯甲酸酯和未反应的β -卤代醇具有良好至优异的对映选择性。通过(1,5-重氮杂环[4.3.0]非5-烯)处理，可将苯甲酸酯转化为相应的烯丙基苯甲酸酯而不损失光学纯度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

Highly efficient kinetic resolution of beta-halohydrins catalyzed by a chiral 1,2-diamine.

Kinetic resolution of racemic beta-halohydrins has been achieved by reaction with benzoyl chloride in the presence of a catalytic amount (0.3 mol%) of a chiral diamine combined with diisopropylethylamine to afford the corresponding benzoates and unreacted beta-halohydrins in good to excellent enantioselectivities. The benzoate can be converted to the corresponding allylic benzoate without loss of optical purity by treatment with (1,5-diazabicyclo[4.3.0]non-5-ene).

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Enantiomer

自引率

0.00%

发文量