宫颈癌的基因组变化和HPV类型。

C P Matthews, K A Shera, J K McDougall
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引用次数: 31

摘要

为了确定可能包括异常表达细胞基因位点的染色体区域,并且可能根据肿瘤的组织学亚型特异性改变,我们使用CGH和HPV基因分型研究了原发性宫颈癌。87%的原发肿瘤呈“高危”HPV型(如16或18型)DNA阳性。在宫颈癌中,不考虑组织学亚型,染色体3q的过代表是最一致的染色体畸变,染色体3p的过代表也是一个常见的发现。染色体臂1q、5p、20q和Xq在许多肿瘤中被过度表达,而3p缺失和5p、8q和16q增加仅与鳞状细胞癌相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genomic changes and HPV type in cervical carcinoma.

To identify chromosomal regions that may include the loci of abnormally expressed cellular genes and may be specifically altered depending on the histological subtype of the tumor, we studied primary cervical carcinoma using CGH and HPV genotyping. Eighty-seven percent of the primary tumors were positive for DNA of a "high-risk" HPV type (e.g., 16 or 18). In the cervical carcinomas, without reference to histologic subtype, overrepresentation of chromosome 3q was the most consistent chromosomal aberration with underrepresentation of chromosome 3p also a frequent finding. Chromosome arms 1q, 5p, 20q, and Xq were overrepresented in many tumors and 3p loss and 5p, 8q, and 16q gain were only associated with squamous cell carcinoma in this series.

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