长期用脱氢表雄酮治疗的Zucker大鼠血清瘦素、脂质、游离脂肪酸和脂肪垫。

R J Richards, J R Porter, F Svec
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引用次数: 7

摘要

肥胖的Zucker大鼠有基因缺陷的瘦素系统,是嗜食、肥胖、高脂血症和瘦素水平明显升高的模型。脱氢表雄酮(DHEA)管理减少贪食,高脂血症和肥胖的朱克大鼠。由于血清瘦素水平与体脂有关,我们想知道脱氢表雄酮(DHEA)减脂对瘦素水平的影响。本实验研究了DHEA对4周龄至20周龄的雄性瘦型和肥胖型Zucker大鼠腹部脂肪垫、血清脂质和外周血瘦素的影响。瘦肉大鼠和肥胖大鼠分别吃普通食物和含有脱氢表雄酮的食物。另外一组瘦鼠、肥胖鼠、体重匹配的对照组和肥胖成对喂养的大鼠,通过DHEA管理,帮助控制体重、食物摄入量和脂肪垫重量的减少。给瘦Zucker大鼠DHEA可使体重和脂肪重量减轻,但瘦素水平呈下降趋势。在肥胖大鼠中,DHEA治疗和配对喂养都能降低体重和脂肪垫重量,但只有DHEA能降低瘦素水平。体重匹配的对照组脂肪垫重量减少,与dhea治疗组相似,但瘦素水平增加。因此,在这种动物模型中,脱氢表雄酮可能对瘦素水平产生小的、独立的影响,但减少的程度低于预期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serum leptin, lipids, free fatty acids, and fat pads in long-term dehydroepiandrosterone-treated Zucker rats.
The obese Zucker rat has a genetically flawed leptin system and is a model of hyperphagia, obesity, hyperlipidemia, and markedly elevated leptin levels. Dehydroepiandrosterone (DHEA) administration reduces hyperphagia, hyperlipidemia, and obesity in Zucker rats. Since serum leptin levels are associated with body fat, we wondered what the effects of fat pad weight reduction from DHEA administration would have on leptin levels. This experiment investigated the effects of DHEA on intra-abdominal fat pads, serum lipids, and peripheral leptin in male lean and obese Zucker rats that were administered DHEA in their food from 4 weeks of age to 20 weeks. Lean and obese rats received plain chow or chow containing DHEA. Additional chow-fed groups of lean and obese weight-matched controls and obese pair-fed rats helped to control for the reduced body weight, food intake, and fat pad weights seen with DHEA administration. DHEA administration to lean Zucker rats reduced body weight and fat pad weights, but leptin level...
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