奥美拉唑抗分泌作用的比较,当静脉注射时,作为酸稳定的颗粒和作为口服膏剂在马。

M L Haven, K Dave, J A Burrow, A M Merritt, D Harris, D Zhang, G J Hickey
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引用次数: 21

摘要

在2匹母马和3匹阉割的公马身上,研究了奥美拉唑对胃酸的抗分泌活性。每匹马都准备了一个慢性胃插管。单次静脉注射奥美拉唑(1.5 mg/kg体重)可有效消除基础和戊胃泌素(PG)刺激的胃酸分泌。每日1次,经鼻胃给药奥美拉唑成酸稳定颗粒,连续5天抑制酸分泌呈剂量依赖性:pg刺激的酸分泌减少57% (1.5 mg/kg体重)和98% (5.0 mg/kg体重)。在19天的治疗期间,每天给药一次,抑制程度保持不变。一个含有酸稳定奥美拉唑颗粒或未包膜奥美拉唑粉末的原型口服膏剂配方与通过鼻胃管给药的类似剂量的酸稳定奥美拉唑颗粒是等效的。含有奥美拉唑粉末的口服膏状制剂具有剂量依赖性抑制作用:5天后,pg刺激的酸分泌减少55% (1.5 mg/kg体重)和77% (3.0 mg/kg体重)。因此,奥美拉唑粉剂的膏状制剂可以为马的胃溃疡疾病提供一种有效的、易于施用的、每日一次的抑酸治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of the antisecretory effects of omeprazole when administered intravenously, as acid-stable granules and as an oral paste in horses.

The antisecretory activity of omeprazole on gastric acid when administered i.v., intragastrically or per os, was evaluated in 2 female and 3 castrated male horses. Each horse had been prepared with a chronic indwelling gastric cannula. A single i.v. administration of omeprazole (1.5 mg/kg bwt) was effective in abolishing basal and pentagastrin (PG)-stimulated acid secretion. Once daily, nasogastric administration of omeprazole in acid-stable granules for 5 days inhibited acid secretion in a dose-dependent manner: 57% (1.5 mg/kg bwt) and 98% (5.0 mg/kg bwt) reduction of PG-stimulated acid secretion. The degree of inhibition was maintained over a 19 day treatment period with once daily dosing. A prototype oral paste formulation containing either acid-stable omeprazole granules or uncoated omeprazole powder was equipotent when compared to a similar dosage of acid-stable omeprazole granules administered by nasogastric tube. A dose-dependent inhibition was seen with the oral paste formulation containing omeprazole powder: 55% (1.5 mg/kg bwt) and 77% (3.0 mg/kg bwt) reduction of PG-stimulated acid secretion after 5 days. Therefore, a paste formulation of omeprazole powder may offer an effective, easily administered, once daily acid inhibitory treatment for gastric ulcer disease in horses.

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