在人类1型神经纤维瘤病(NF1)基因的5'区发现了一种新颖且非常特殊的HincII多态性。

Annales de genetique Pub Date : 1999-01-01

L J Fang, J Feingold, B Lemieux, J P Thirion

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摘要

我们报告了在神经纤维瘤病1型基因(NF1)的5'端检测到HincII多态性，该多态性由外显子1至4a (cDNA的核苷酸2至401)组成的探针检测到。这个HincII位点很可能位于内含子中。提出的证据表明，该探针揭示了不是一种而是两种相似的多态性。

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A novel and very peculiar HincII polymorphism in the 5' region of the human neurofibromatosis type 1 (NF1) gene.

We report a HincII polymorphism in the 5' end of the neurofibromatosis type 1 gene (NF1) as detected with a probe made of exons 1 to 4a (nucleotides 2 to 401 of the cDNA). This HincII site is most probably in an intron. Evidence presented suggests the probe reveals not one but two similar polymorphisms.

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Annales de genetique

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