{"title":"9-(β - l -阿拉伯糖脲基)腺嘌呤的合成及生物学评价。","authors":"V Boudou, J L Imbach, G Gosselin","doi":"10.1080/07328319908044620","DOIUrl":null,"url":null,"abstract":"<p><p>For the first time, the stereospecific synthesis of 9-(beta-L-arabinofuranosyl) adenine was carried out. Unfortunately, and unlike its \"natural\" D-counterpart Vidarabine, this L-enantiomer did not show significant activity when evaluated against a broad range of viruses.</p>","PeriodicalId":19222,"journal":{"name":"Nucleosides & nucleotides","volume":"18 11-12","pages":"2463-73"},"PeriodicalIF":0.0000,"publicationDate":"1999-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07328319908044620","citationCount":"1","resultStr":"{\"title\":\"Synthesis and biological evaluation of 9-(beta-L-arabinofuranosyl)adenine.\",\"authors\":\"V Boudou, J L Imbach, G Gosselin\",\"doi\":\"10.1080/07328319908044620\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>For the first time, the stereospecific synthesis of 9-(beta-L-arabinofuranosyl) adenine was carried out. Unfortunately, and unlike its \\\"natural\\\" D-counterpart Vidarabine, this L-enantiomer did not show significant activity when evaluated against a broad range of viruses.</p>\",\"PeriodicalId\":19222,\"journal\":{\"name\":\"Nucleosides & nucleotides\",\"volume\":\"18 11-12\",\"pages\":\"2463-73\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1999-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/07328319908044620\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nucleosides & nucleotides\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/07328319908044620\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nucleosides & nucleotides","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/07328319908044620","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
首次进行了立体定向合成9-(β - l -阿拉伯糖脲基)腺嘌呤。不幸的是，与“天然的”d对映体阿糖腺苷不同，这种l对映体在对多种病毒进行评估时没有显示出显著的活性。
Synthesis and biological evaluation of 9-(beta-L-arabinofuranosyl)adenine.
For the first time, the stereospecific synthesis of 9-(beta-L-arabinofuranosyl) adenine was carried out. Unfortunately, and unlike its "natural" D-counterpart Vidarabine, this L-enantiomer did not show significant activity when evaluated against a broad range of viruses.
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