R Villaescusa, A M Guerreiro, J C Merlín, L Mireya Morera, E Espinosa, J M Ballester, P Hernández
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[Antineutrophil cytoplasmic antibodies in patients with sickle cell anemia].
Purpose: To determine whether anti neutrophil cytoplasmic antibodies (ANCA): anti myeloperoxidase (anti MPO) and anti proteinase 3 (anti PR3), are present in patients with sickle cell anaemia (SCA) during painful crisis.
Patients and methods: 55 patients with SCA were included in this study, 35 of them had painful crisis and the rest were in steady state. We determined levels of anti MPO and anti PR3 by two enzyme immunoassays commercially available (Progen Biotechnik GMBH).
Results: A significant increase of anti MPO in the group of patients with painful crisis was found in comparison with steady state patients and controls.
Conclusions: Our results suggest the possibility that anti MPO interacting with MPO on primed neutrophils lead to neutrophil activation, enhanced neutrophil adhesion and amplification of endothelial cell damage.
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