新核苷类似物的合成包括双氟环丙烷片段作为潜在的抗病毒/抗肿瘤药物。

Y L Qiu, J Zemlicka
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引用次数: 3

摘要

合成了核苷7a-7e的双氟环丙烷类似物。化合物7a和7c-7e由核酸碱基或相应的前体与(顺式)-1-苄基氧甲基-2-溴甲基-3,3-二氟环丙烷++ +(8)烷基化而得。类似物7b由2-氨基-6-氯嘌呤衍生物7e水解而得。化合物7a-7d对HCMV、HSV-1、HSV-2、EBV、VZV、HBV和HIV-1没有抗病毒活性,对小鼠白血病L1210、小鼠肿瘤PO3或C38和人肿瘤H15没有抗肿瘤作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis of new nucleoside analogues comprising a geminal difluorocyclopropane moiety as potential antiviral/antitumor agents.

Geminal difluorocyclopropane analogues of nucleosides 7a-7e were synthesized. Compounds 7a and 7c-7e were obtained by alkylation of nucleic acid bases or their appropriate precursors with (cis)-1-benzyloxymethyl-2-bromomethyl-3,3-difluorocyclopropane+ ++ (8). Analogue 7b was prepared by hydrolysis of 2-amino-6-chloropurine derivative 7e. Compounds 7a-7d did not exhibit any antiviral activity against HCMV, HSV-1, HSV-2, EBV, VZV, HBV and HIV-1 or antitumor effects against murine leukemia L1210, mouse tumors PO3 or C38 and human tumor H15.

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