一种高选择性腺苷A2a受体激动剂的合成及其生物活性。

Nucleosides & nucleotides Pub Date : 1999-10-01 DOI:10.1080/07328319908044874

D R Borcherding, N L Lentz, P M Weintraub, M W Dudley, R Secrest, P R Kastner, N P Peet

{"title":"一种高选择性腺苷A2a受体激动剂的合成及其生物活性。","authors":"D R Borcherding, N L Lentz, P M Weintraub, M W Dudley, R Secrest, P R Kastner, N P Peet","doi":"10.1080/07328319908044874","DOIUrl":null,"url":null,"abstract":"Three novel nucleosides 1, 2, and 3 were prepared that contained side chains at the 2-position of adenosine. Compound 1 was shown to be the most selective A2a receptor agonist reported to date having an A1/A2 ratio of 2400. In addition, compound 1 was shown to reduce blood pressure in rats and dogs with only minimal effects on heart rate.","PeriodicalId":19222,"journal":{"name":"Nucleosides & nucleotides","volume":"18 10","pages":"2175-91"},"PeriodicalIF":0.0000,"publicationDate":"1999-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07328319908044874","citationCount":"5","resultStr":"{\"title\":\"The synthesis and biological activity of a highly selective adenosine A2a receptor agonist.\",\"authors\":\"D R Borcherding, N L Lentz, P M Weintraub, M W Dudley, R Secrest, P R Kastner, N P Peet\",\"doi\":\"10.1080/07328319908044874\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Three novel nucleosides 1, 2, and 3 were prepared that contained side chains at the 2-position of adenosine. Compound 1 was shown to be the most selective A2a receptor agonist reported to date having an A1/A2 ratio of 2400. In addition, compound 1 was shown to reduce blood pressure in rats and dogs with only minimal effects on heart rate.\",\"PeriodicalId\":19222,\"journal\":{\"name\":\"Nucleosides & nucleotides\",\"volume\":\"18 10\",\"pages\":\"2175-91\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1999-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/07328319908044874\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nucleosides & nucleotides\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/07328319908044874\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nucleosides & nucleotides","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/07328319908044874","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 5

摘要

制备了三种新的核苷1、2和3，它们在腺苷的2位上含有侧链。化合物1是迄今为止报道的最具选择性的A2a受体激动剂，A1/A2比值为2400。此外，化合物1被证明可以降低大鼠和狗的血压，而对心率的影响很小。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

The synthesis and biological activity of a highly selective adenosine A2a receptor agonist.

Three novel nucleosides 1, 2, and 3 were prepared that contained side chains at the 2-position of adenosine. Compound 1 was shown to be the most selective A2a receptor agonist reported to date having an A1/A2 ratio of 2400. In addition, compound 1 was shown to reduce blood pressure in rats and dogs with only minimal effects on heart rate.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nucleosides & nucleotides

自引率

0.00%

发文量