b型流感嗜血杆菌结合疫苗(hititer)的免疫原性以及hititer和白喉、破伤风、百日咳和hititer联合疫苗在两个月龄婴儿中的安全性:初步报告

P F Chang, L M Huang, P I Lee, H H Chiu, S Y Tasi, C Y Lee
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引用次数: 0

摘要

进行了一项研究,以评估b型流感嗜血杆菌(Hib)结合疫苗(hititer)与百白破(白喉、破伤风和百日咳)疫苗在单独注射器中同时使用时的安全性和免疫原性。在台湾,共有90名健康儿童(每组45名)随机接受TETRAMUNE,一种将HibTITER与全细胞百白破联合接种的疫苗(A组),或在大约2、4和6个月大时,在单独的注射器中同时接种DTP和HibTITER (B组)。B组儿童抗hib PRP抗体滴度均高于0.15微克/毫升,91%的儿童在第三次免疫后抗体滴度高于1.0微克/毫升。不良反应发生率在A组和b组之间具有可比性,而且不良反应发生率与单独接种百白破疫苗相比没有明显增加。我们的结论是,当与百白破疫苗同时使用时,HibTITER对台湾儿童具有高度的免疫原性和安全性。TETRAMUNE也是安全的,未来可能会减少注射次数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immunogenicity of Haemophilus influenzae b conjugate vaccine (HibTITER) and safety of HibTITER and a combination vaccine of diphtheria, tetanus, pertussis and HibTITER in infants two months of age: a preliminary report.

A study was undertaken to evaluate the safety and immunongenicity of a conjugate Haemophilus influenzae type b (Hib) vaccine (HibTITER) when administered concurrently with DTP (diphteria, tetanus and pertussis) vaccine in separate syringes. A total of 90 healthy children (45 per group) were randomized to receive either TETRAMUNE, a vaccine combining HibTITER with whole-cell DTP (group A), or DTP and HibTITER administered concurrently (group B) in separate syringes at approximately 2, 4 and 6 months of age in Taiwan. All children in group B achieved anti-Hib PRP (polyribosylribitol phosphate) antibody titers above 0.15 microgram/ml and 91% developed antibody titers above 1.0 microgram/ml following the third immunization. Incidences of adverse reactions were comparable between groups A and B. Besides, the incidences of adverse reactions were not significantly more frequent compared with DTP vaccination alone. We concluded that HibTITER was highly immunogenic and safe when administered concurrently with DTP vaccine to Taiwanese children. TETRAMUNE was also safe and the number of injections may be reduced in the future.

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