氮杂丁-2-羧酸对单次或分次x射线治疗肝癌细胞的影响以及对正常和耐热细胞的热致敏作用。

J van Rijn, J van den Berg, C A van der Mast
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引用次数: 2

摘要

氨基酸类似物氮杂啶-2-羧酸(氮杂啶)是对高温和电离辐射的有效敏化剂。在x射线治疗前后用2.5 mM azetidine孵育H35肝癌细胞,可引起细胞杀伤的时间和序列依赖性增强。将细胞暴露于1-1.5 mM氮杂啶96小时,同时每隔24小时进行3 Gy x射线的重复剂量,由于放射致敏和额外的生长抑制,导致存活细胞数量的增加。Azetidine不能阻止热休克后耐热性的诱导。这种耐热性按比例降低热放射致敏性,但似乎不影响氮杂啶的放射致敏性。热辐射敏化和氮杂啶辐射敏化的作用机制不同。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of azetidine-2-carboxylic acid on treatments of hepatoma cells with single or fractionated X-ray irradiations and on thermal radiosensitization in normal and thermotolerant cells.

The amino acid analog azetidine-2-carboxylic acid (azetidine) is a potent sensitizer to both hyperthermia and ionizing radiation. Incubation of H35 hepatoma cells with 2.5 mM azetidine before or after treatments with X-rays causes a time- and sequence-dependent enhancement of cell killing. Exposure of cells to 1-1.5 mM azetidine for 96 h in combination with repeated doses of 3 Gy X-rays at 24 h intervals causes an enhanced reduction of the surviving cell population due to both radiosensitization and an additional growth inhibition. Azetidine does not prevent the induction of thermotolerance after a heat shock. This thermotolerance proportionally reduces thermal radiosensitization but does not seem to affect azetidine radiosensitization. It is suggested that thermal radiosensitization and azetidine radiosensitization operate by different mechanisms.

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