利用电离辐射加强基于病毒的基因治疗的策略。

S J Chmura, S J Advani, D W Kufe, R R Weichselbaum
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引用次数: 18

摘要

许多正在研究的基因治疗策略旨在提高当前癌症治疗方案的疗效。在实验室和早期临床试验中,利用专门设计的基于病毒的基序来增强电离辐射或化疗的疗效,已经获得了令人鼓舞的结果。这些策略可分为两大类:用于传递编码化学/辐射调节剂的特定基因的复制能力不强的病毒穿梭载体,以及在肿瘤细胞中具有复制优势的弱复制能力病毒。本文综述了这些策略的原理、分子机制和临床应用,重点介绍了近年来应用这些基于病毒的策略提高电离辐射治疗指标的研究进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Strategies for enhancing viral-based gene therapy using ionizing radiation.

Many gene-therapy strategies under investigation aim to increase the efficacy of current cancer-treatment regimens. Promising results have been obtained in the laboratory and early clinical trials using viral-based motifs specifically designed to enhance the efficacy of ionizing radiation or chemotherapy. These strategies fall into two general categories: replication-incompetent viral shuttle vectors for the delivery of specific genes encoding a chemo/radiation modulator and attenuated replication-competent viruses with proposed replicative advantages in tumor cells. In this review, we discuss the rational, molecular mechanisms, and clinical application of these strategies with particular focus on recent research applying these viral-based strategies to improve the therapeutic index of ionizing radiation.

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