癌症中的血管生成和血管生成抑制剂。

Forum (Genoa, Italy) Pub Date : 1999-07-01
R Giavazzi, G Taraboletti
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引用次数: 0

摘要

血管生成,即新血液供应的发展,是肿瘤生长和转移的重要过程。在过去的几年里,这导致了肿瘤血管系统作为抗癌策略的最佳目标的考虑。血管生成的过程由一系列相互作用的事件组成:静止的内皮细胞在血管生成因子的刺激下降解底层的基底膜,在间质基质内迁移,增殖并将自己组织成管状结构,成为成熟的血管。在血管生成过程中,内皮细胞发生功能变化,表现出不同于正常的、静止的内皮细胞的分子特征。这些差异可以被用来选择性地靶向肿瘤内皮并防止新血管的形成。主要有两种方法:1 .抑制血管生成过程和血管形成(抗血管生成);直接靶向和破坏肿瘤血管(血管靶向)。不同来源和作用机制的化合物都有抑制血管生成从而抑制肿瘤生长的潜力。本文综述了一些正在开发的血管生成拮抗剂和临床试验中用于治疗癌症的先导化合物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Angiogenesis and angiogenesis inhibitors in cancer.

Angiogenesis, the development of a new blood supply, is an essential process of tumour growth and metastasis. Over the past few years, this has led to the consideration of the tumour vasculature as an optimal target for anti-cancer strategies. The process of angiogenesis consists of a series of interactive events: quiescent endothelial cells are stimulated by angiogenic factors to degrade the underlying basement membrane, to migrate within the interstitial matrix, to proliferate and to organise themselves into tubular structures which become mature blood vessels. During angiogenesis, the endothelial cells undergo functional changes and show molecular features which are different from normal, quiescent endothelium. These differences can be exploited in order to selectively target tumour endothelium and to prevent neo-vessel formation. Two main approaches have been followed: i. the inhibition of the angiogenic process and vessel formation (anti-angiogenesis), and ii. direct targeting and destruction of tumour vasculature (vascular targeting). Compounds of different origin and mechanism of action have the potential to inhibit angiogenesis and hence tumour growth. This review takes into consideration some angiogenesis antagonists that are in development and the leader compounds that are under clinical trial for the treatment of cancer.

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