I K Brenner, V M Natale, P Vasiliou, A I Moldoveanu, P N Shek, R J Shephard
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Blood samples were analyzed for CK, natural killer (NK) cell counts (CD3(-)/CD16(+)56(+)), cytolytic activity and plasma levels of the cytokines interleukin (IL)-6, IL-10, and tissue necrosis factor alpha (TNF-alpha). CK levels were only elevated significantly 72 h following CT. NK cell counts increased significantly during all three types of exercise, but returned to pre-exercise baseline values within 3 h of recovery. Cytolytic activity per NK cell was not significantly modified by any type of exercise. Prolonged exercise induced significant increases in plasma IL-6 and TNF-alpha. We conclude that the lack of correlation between traditional markers of muscle injury (plasma CK concentrations and muscle soreness rankings) and immune markers of the inflammatory response suggests that, for the types and intensities of exercise examined in this study, the exercise-induced inflammatory response is modified by humoral and cardiovascular correlates of exercise.</p>","PeriodicalId":11936,"journal":{"name":"European Journal of Applied Physiology and Occupational Physiology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1999-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s004210050617","citationCount":"157","resultStr":"{\"title\":\"Impact of three different types of exercise on components of the inflammatory response.\",\"authors\":\"I K Brenner, V M Natale, P Vasiliou, A I Moldoveanu, P N Shek, R J Shephard\",\"doi\":\"10.1007/s004210050617\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>It was hypothesized that muscle injury would be greater with eccentric than with all-out or prolonged exercise, and that immune changes might provide an indication that supplements the information provided by traditional markers such as creatine kinase (CK) or delayed-onset muscle soreness. Eight healthy males [mean (SE): age = 24.9 (2.3) years, maximum oxygen consumption (VO2(max)) = 43.0 (3.1) ml x kg(-1) x min(-1)] were each assigned to four experimental conditions, one at a time, using a randomized-block design: 5 min of cycle ergometer exercise at 90% VO2(max) (AO), a standard circuit-training routine (CT), 2 h cycle ergometer exercise at 60% VO2(max) (Long), or remained seated for 5 h. Blood samples were analyzed for CK, natural killer (NK) cell counts (CD3(-)/CD16(+)56(+)), cytolytic activity and plasma levels of the cytokines interleukin (IL)-6, IL-10, and tissue necrosis factor alpha (TNF-alpha). CK levels were only elevated significantly 72 h following CT. NK cell counts increased significantly during all three types of exercise, but returned to pre-exercise baseline values within 3 h of recovery. Cytolytic activity per NK cell was not significantly modified by any type of exercise. Prolonged exercise induced significant increases in plasma IL-6 and TNF-alpha. 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引用次数: 157
摘要
假设偏心运动的肌肉损伤比全力以赴或长时间运动更严重,免疫变化可能提供了一种指示,补充了传统标记(如肌酸激酶(CK)或延迟性肌肉酸痛)提供的信息。8名健康男性[平均(SE):年龄= 24.9(2.3)岁,最大耗氧量(VO2(max)) = 43.0 (3.1) ml x kg(-1) x min(-1)],采用随机分组设计,每次分配4个实验条件:以90% VO2(max) (AO)进行5分钟的循环运动,进行标准的循环训练(CT),以60% VO2(max)进行2小时的循环运动(Long),或保持坐姿5小时。分析血液样本的CK,自然杀伤(NK)细胞计数(CD3(-)/CD16(+)56(+)),细胞溶解活性和血浆细胞因子白细胞介素(IL)-6, IL-10和组织坏死因子α (tnf - α)水平。CK水平仅在CT后72小时显著升高。NK细胞计数在所有三种类型的运动中都显著增加,但在恢复后3小时内恢复到运动前的基线值。每个NK细胞的细胞溶解活性没有被任何类型的运动显著改变。长时间运动导致血浆IL-6和tnf - α显著增加。我们的结论是,传统的肌肉损伤标志物(血浆CK浓度和肌肉酸痛等级)与炎症反应的免疫标志物之间缺乏相关性,这表明,对于本研究中检测的运动类型和强度,运动诱导的炎症反应被运动的体液和心血管相关因素所改变。
Impact of three different types of exercise on components of the inflammatory response.
It was hypothesized that muscle injury would be greater with eccentric than with all-out or prolonged exercise, and that immune changes might provide an indication that supplements the information provided by traditional markers such as creatine kinase (CK) or delayed-onset muscle soreness. Eight healthy males [mean (SE): age = 24.9 (2.3) years, maximum oxygen consumption (VO2(max)) = 43.0 (3.1) ml x kg(-1) x min(-1)] were each assigned to four experimental conditions, one at a time, using a randomized-block design: 5 min of cycle ergometer exercise at 90% VO2(max) (AO), a standard circuit-training routine (CT), 2 h cycle ergometer exercise at 60% VO2(max) (Long), or remained seated for 5 h. Blood samples were analyzed for CK, natural killer (NK) cell counts (CD3(-)/CD16(+)56(+)), cytolytic activity and plasma levels of the cytokines interleukin (IL)-6, IL-10, and tissue necrosis factor alpha (TNF-alpha). CK levels were only elevated significantly 72 h following CT. NK cell counts increased significantly during all three types of exercise, but returned to pre-exercise baseline values within 3 h of recovery. Cytolytic activity per NK cell was not significantly modified by any type of exercise. Prolonged exercise induced significant increases in plasma IL-6 and TNF-alpha. We conclude that the lack of correlation between traditional markers of muscle injury (plasma CK concentrations and muscle soreness rankings) and immune markers of the inflammatory response suggests that, for the types and intensities of exercise examined in this study, the exercise-induced inflammatory response is modified by humoral and cardiovascular correlates of exercise.