高原肺水肿易感者脑血流速度对缺氧的反应。

J Berré, J L Vachiéry, J J Moraine, R Naeije
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引用次数: 16

摘要

暴露在高海拔地区时,脑血流量会增加,急性高原反应患者的脑血流量可能会增加。我们通过经颅多普勒超声检测大脑中动脉在海平面、常氧(吸入O2分数,F(I)O2 0.21)和缺氧(F(I)O2 0.125)或高氧(F(I)O2 1.0)呼吸15分钟期间的脑血流量,其中包括7名既往患有高原肺水肿的受试者,6名先前耐受海拔在6000米至8150米之间的登山者,以及20名未选择的对照组。缺氧使平均大脑中动脉血流速度从69(3)增加到83 (4)cm × s(-1)
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cerebral blood flow velocity responses to hypoxia in subjects who are susceptible to high-altitude pulmonary oedema.

Cerebral blood flow increases on exposure to high altitude, and perhaps more so in subjects who develop acute mountain sickness. We determined cerebral blood flow by transcranial Doppler ultrasound of the middle cerebral artery at sea level, in normoxia (fraction of inspired O2, F(I)O2 0.21), and during 15-min periods of either hypoxic (F(I)O2 0.125) or hyperoxic (F(I)O2 1.0) breathing, in 7 subjects with previous high-altitude pulmonary oedema, 6 climbers who had previously tolerated altitudes between 6000 m and 8150 m, and in 20 unselected controls. Hypoxia increased mean middle cerebral artery flow velocity from 69 (3) to 83 (4) cm x s(-1) (P<0.001) in the controls, from 63 (3) to 75 (3) cm x s(-1) (P<0.001) in the high-altitude pulmonary-oedema-susceptible subjects, and from 58 (4) to 70 (4) cm x s(-1) (P<0.001) in the successful high-altitude climbers. Hyperoxia decreased mean middle cerebral flow velocity to 60 (3) cm x s(-1) (P<0.001), 53 (3) cm x s(-1) (P<0.01), and 49 (3) cm x s(-1) (P<0.01) in the controls, high-altitude pulmonary-oedema-susceptible, and high-altitude climbers, respectively. We conclude that a transcranial Doppler-based estimate of cerebral blood flow is affected by hypoxic and hyperoxic breathing, and that it is not predictive of tolerance to high altitude.

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