注意:谨慎使用药效学间接反应模型的经验方程。

Journal of Pharmacokinetics and Biopharmaceutics Pub Date : 1998-12-01 DOI:10.1023/a:1020707208521

W Krzyzanski, W J Jusko

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引用次数: 2

摘要

最近提出了一个经验方程，并用于表征抑制药物对内源性物质生产的影响。利用数学方程和基于间接响应模型i的精确微分方程的模拟来描述该经验方程的局限性。后者更适合使用间接响应模型拟合数据。

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Note: caution in use of empirical equations for pharmacodynamic indirect response models.

An empirical equation was recently proposed and used to characterize inhibitory drug effects on production of an endogenous substance. The limitations of this empirical equation are described utilizing mathematical equations and simulations based on the exact differential equation for Indirect Response Model I. The latter is preferable for fitting data using indirect response models.

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Journal of Pharmacokinetics and Biopharmaceutics

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