睾丸切除术前耐力跑是否能预防大鼠骨质减少?

M N Horcajada-Molteni, M J Davicco, H Collignon, P Lebecque, V Coxam, J P Barlet
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引用次数: 11

摘要

本实验旨在研究睾丸切除前3个月耐力训练对大鼠股骨的影响。选用8周龄雄性Wistar大鼠70只。实验第0天,取颈脱臼致死大鼠10只作为第一对照组。在其他60只小鼠中,选择30只进行跑步机训练(60%最大摄氧量,每天1小时(-1),每周6天(-1),共90天)。另外30只老鼠则保持休息状态。第90天,处死10只运动(IE)和静止(IR)大鼠作为中间对照。每组20只,手术阉割(CXE、CXR) 10只,假手术(SHE、SHR) 10只,于第180天处死。第90天,IE组股骨失效负荷(三点弯曲试验)大于IR组。同时,IE组脱氧吡啶尿量低于IR组。第180天,CXR组股骨比CXE组薄。CXE和CXR大鼠股骨小梁骨的最低值在股骨远端干骺端,但CXE与SHR的测量值无明显差异。同时,CXR组股骨总骨密度低于SHE组,而CXE组与SHR组股骨干骺端密度无差异。这些结果证实,耐力跑步增加了8月龄雄性大鼠的股骨骨生长和建模以及股骨小梁面积,从而达到骨量峰值。在训练结束后阉割的静息动物中,雄激素缺乏降低了股骨密度、矿物质含量和小梁面积。这种下降在阉割但先前运动过的大鼠中没有观察到。因此,通过增加峰值骨量,耐力训练被认为可能对兰花切除术引起的骨质流失有预防作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Does endurance running before orchidectomy prevent osteopenia in rats?

This experiment was performed to study the effects on femoral bone of endurance training performed during the 3 months before orchidectomy in rats which were then killed 90 days later. A total of 70 male Wistar rats were used at 8 weeks old. One day 0 of the experiment, 10 rats were killed by cervical dislocation and used as first controls. Among the 60 others, 30 were selected for treadmill running (60% maximal oxygen uptake, 1 h x day(-1), 6 days x week(-1) for 90 days). The 30 other rats remained at rest. On day 90, 10 exercised (IE) and resting (IR) rats were killed and used as intermediary controls. Among the 20 other animals of each group, 10 were surgically castrated (CXE, CXR) or 10 sham-operated (SHE, SHR) and killed on day 180. On day 90 femoral failure load (three-point bending test) was greater in IE than in IR. Simultaneously, the deoxypyridinolinuria was lower in IE than in IR. On day 180, femoral bones were thinner in CXR than in CXE. The lowest values for trabecular bone are in the distal femoral metaphysis were measured in CXE and CXR rats, but the value measured in CXE was no different from that measured in SHR. Simultaneously total femoral bone density was lower in CXR than in SHE, while no difference concerning femoral metaphyseal density was observed between CXE and SHR. These results confirmed that endurance running increased femoral bone growth and modelling and femoral trabecular area, and thereby peak bone mass, in 8-month-old male rats. In resting animals, castrated after the training period, androgen deficiency decreased femoral density, mineral content and trabecular area. This decrease was not observed in castrated but previously exercised rats. Thus, by increasing peak bone mass, it was considered that endurance training may have a preventive effect against orchidectomy-induced bone loss.

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