镁和镁/聚r(A-U)组合对两种RNA病毒的抗病毒活性。

Nucleosides & nucleotides Pub Date : 1999-06-01 DOI:10.1080/07328319908044668

J Jamison, J Gilloteaux, M R Nassiri, C C Tsai, J Summers

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引用次数: 1

摘要

镁(Mg2+)增强了聚r(A-U)或聚r(G-C)抗水疱性口炎病毒(VSV)的活性以及聚r(A-U)抗hiv -1的活性。Mg2+不影响poly (rI)的抗vsv活性。poly (rC)， poly (dA-dT)。聚(dA-dT)或聚(dG-dC)。保利(dG-dC)。宿主细胞的一个或多个核(核仁)过程的调节可能是协同抗病毒活性的原因。

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Antiviral activity of magnesium and magnesium/poly r(A-U) combinations against two RNA viruses.

Magnesium (Mg2+) potentiated the anti-vesicular stomatitis virus (VSV) activity of poly r(A-U) or poly r(G-C) and the anti-HIV-1 activity of poly r(A-U). Mg2+ did not affect the anti-VSV activity of poly (rI).poly (rC), poly (dA-dT).poly (dA-dT) or poly (dG-dC).poly (dG-dC). Modulation of one or more nuclear (nucleolar) processes of the host cell may be responsible for the synergistic antiviral activity.

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Nucleosides & nucleotides

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