脂质X的碳环类似物的合成和生物学评价:LPS诱导TNF生成的新非极性拮抗剂。

Drug design and discovery Pub Date : 1999-07-01

S Augy-Dorey, D C Billington, J A Camara, S D Gero, I Sagnard, B Quiclet-Sire, D Ghezzi

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引用次数: 0

摘要

我们已经合成了许多脂质X的类似物，脂质X是LPS生物合成的前体，其中一些在体内表现出明显的LPS诱导TNF生成的拮抗作用。这些化合物为寻找治疗内毒素休克的方法提供了新的非极性线索。

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Synthesis and biological evaluation of carbocyclic analogues of lipid X: new nonpolar antagonists of LPS induced TNF production.

We have synthesised a number of analogues of lipid X, a precursor in the biosynthesis of LPS, some of which exhibit marked antagonism of LPS induced TNF production in vivo. These compounds provide new non-polar leads in the search for a therapy for endotoxic shock.

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Drug design and discovery

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