朗格汉斯小岛的一千面。

P M Pour, B M Schmied
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引用次数: 16

摘要

对叙利亚仓鼠和叙利亚金仓鼠不同品系的研究表明,胰岛细胞具有发生原位和异位化生的显著潜力。最常见的自发变化包括老龄和营养不良仓鼠肝细胞的发育。在癌变过程中发生的许多其他改变中,大多数化生改变起源于胰岛周围,并在胰岛内外进展。最常见的改变是胰岛内的管状结构的发展及其发展为与人类浆液性囊腺瘤或高度侵袭性腺癌相同的结构。胰岛内产生的癌细胞具有明显更大的侵袭潜力,与导管内肿瘤生长缓慢形成鲜明对比(导管内肿瘤)。对人体组织的研究也显示了胰岛内恶性细胞的发展,在某些情况下,胰岛细胞向恶性细胞转变。总体结果,以及最近在培养的人类和仓鼠胰岛的其他研究中发现,表明胰岛细胞分化和发生恶性转化的巨大潜力。化生细胞和恶性细胞是来自于嵌入胰岛内的干细胞还是来自于转分化的胰岛细胞还有待观察。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
One thousand faces of Langerhans islets.

Studies with different strains of Syrian hamsters and Syrian golden hamsters have revealed the remarkable potential of islet cells to undergo orthotopic and heterotopic metaplasia. The most common spontaneous change included the development of hepatocytes in aged and malnourished hamsters. Of the many other alterations that occurred during carcinogenesis, most of the metaplastic changes originated within the islet periphery and progressed inside and outside the islets. The development of ductular structures within islets and their progression either to structures identical to human serous cystadenoma or to highly invasive adenocarcinomas were the most common alterations. The remarkably greater invasive potential of cancer cells arising within the islets contrasted sharply with the slow growth of the tumors developing within ducts (intraductal tumors). Studies in human tissue also showed development of malignant cells within islets, and, in some cases, transition of islet cells to malignant cells was suggested. The overall results, along with recent findings in other studies in cultured human and hamster islets, indicate the enormous potential of islet cells to differentiate and undergo malignant transformation. Whether the metaplastic and malignant cells derive from stem cells embedded within islets or from transdifferentiated islet cells remains to be seen.

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