{"title":"[瘢痕疙瘩和正常皮肤三部分成纤维细胞对白细胞介素-1 β和白细胞介素-6的反应]。","authors":"S Xu, Z Wang, W Bao","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to explore the responses of fibroblasts from keloids and normal skin to interleukin-1 beta and interleukin-6.</p><p><strong>Methods: </strong>Six samples of keloids and 6 samples of normal skin were collected as the experimental and control group respectively. The means of cell culture was used to investigate the responses of fibroblasts from three different parts of keloids and normal skin to interleukin-1 beta (200 U/ml) and interleukin-6 (100 U/ml).</p><p><strong>Results: </strong>Interleukin-1 beta could inhibit the growth of fibroblasts from the proliferative part of keloids but stimulate growth of those from normal skin, while it did not affect the growth of those from other parts of keloids. Fibroblasts from different parts of keloids and normal skin were all inhibited by interleukin-6.</p><p><strong>Conclusion: </strong>The responses of fibroblasts from three parts of keloids and normal skin to interleukin-1 beta and interleukin-6 were not much similar.</p>","PeriodicalId":77478,"journal":{"name":"Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns","volume":"14 1","pages":"23-5"},"PeriodicalIF":0.0000,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[The responses of fibroblasts from three parts of keloids and normal skin to interleukin-1 beta and interleukin-6].\",\"authors\":\"S Xu, Z Wang, W Bao\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The purpose of this study was to explore the responses of fibroblasts from keloids and normal skin to interleukin-1 beta and interleukin-6.</p><p><strong>Methods: </strong>Six samples of keloids and 6 samples of normal skin were collected as the experimental and control group respectively. The means of cell culture was used to investigate the responses of fibroblasts from three different parts of keloids and normal skin to interleukin-1 beta (200 U/ml) and interleukin-6 (100 U/ml).</p><p><strong>Results: </strong>Interleukin-1 beta could inhibit the growth of fibroblasts from the proliferative part of keloids but stimulate growth of those from normal skin, while it did not affect the growth of those from other parts of keloids. Fibroblasts from different parts of keloids and normal skin were all inhibited by interleukin-6.</p><p><strong>Conclusion: </strong>The responses of fibroblasts from three parts of keloids and normal skin to interleukin-1 beta and interleukin-6 were not much similar.</p>\",\"PeriodicalId\":77478,\"journal\":{\"name\":\"Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns\",\"volume\":\"14 1\",\"pages\":\"23-5\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1998-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[The responses of fibroblasts from three parts of keloids and normal skin to interleukin-1 beta and interleukin-6].
Objective: The purpose of this study was to explore the responses of fibroblasts from keloids and normal skin to interleukin-1 beta and interleukin-6.
Methods: Six samples of keloids and 6 samples of normal skin were collected as the experimental and control group respectively. The means of cell culture was used to investigate the responses of fibroblasts from three different parts of keloids and normal skin to interleukin-1 beta (200 U/ml) and interleukin-6 (100 U/ml).
Results: Interleukin-1 beta could inhibit the growth of fibroblasts from the proliferative part of keloids but stimulate growth of those from normal skin, while it did not affect the growth of those from other parts of keloids. Fibroblasts from different parts of keloids and normal skin were all inhibited by interleukin-6.
Conclusion: The responses of fibroblasts from three parts of keloids and normal skin to interleukin-1 beta and interleukin-6 were not much similar.
![Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns](/Content/css/sci/img/zetp.jpg)
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