白叶的植物毒性木脂素。

A M Rimando, F E Dayan, J R Mikell, R M Moraes
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引用次数: 30

摘要

白叶正己烷:乙酸乙酯(1:1)萃取物的生物测定引导分馏通过i.m.j johnst (schrophulariaceae)的研究,分离得到其植物毒性成分diayangambin(1)、epiyangambin(2)、diasesartemin(3)和epiashantin(4)。24孔板微测定法研究了锦绣草(禾本科)和紫菀(菊科)幼苗发育的抑制作用。其中化合物1对L. sativa的植物毒性最强,在110 μ m下表现出较强的抑制活性。化合物1的I(50)值分别为160、670和930 μ m,对匍匐茎生长的抑制作用强于化合物2和3。在500 μ m浓度下,这些化合物抑制洋葱根细胞分裂的各个阶段。这是首次证明这些呋喃木脂素具有抗有丝分裂活性,也是首次从该物种中分离到它们的报道。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Phytotoxic lignans of Leucophyllum frutescens.

Bioassay-guided fractionation of the hexane:ethyl acetate (1:1) extract of the leaves of Leucophyllum frutescens (Berl.) I.M.Johnst (Scrophulariaceae) led to the isolation of its phytotoxic constituents diayangambin (1), epiyangambin (2), diasesartemin (3) and epiashantin (4). Phytotoxicity was demonstrated as inhibition of seed germination of Agrostis stolonifera cv. penncross (Poaceae) and inhibition of development of Lactuca sativa L. (Asteraceae) seedlings in a microassay using 24-well plates. Compound 1 was the most phytotoxic to L. sativa, showing strong inhibitory activity at 110 microM. Compound 1 was more active than 2 and 3 in inhibiting the growth of A. stolonifera with I(50) values of 160, 670 and 930 microM, respectively. At a concentration of 500 microM, these compounds inhibited all phases of onion root cell division. This is the first demonstration of antimitotic activity of these furofuran lignans, and the first report of their isolation from this species.

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