口腔病原体牙龈卟啉单胞菌的侵袭策略:对心血管疾病的影响。

R G Deshpande, M Khan, C A Genco
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引用次数: 96

摘要

微生物已经进化出多种机制来逃避宿主的检测和/或破坏。许多病原体通过入侵细胞来逃避宿主的防御,从而为细菌提供了一个没有竞争微生物的环境。黏附和侵袭是活跃的过程,微生物通常利用宿主蛋白质和酶进入细胞,从而刺激自身的摄取。与肠道病原菌相比,对牙龈卟啉单胞菌侵袭的研究尚处于起步阶段。然而,最近对牙龈假单胞菌的研究表明,这些生物对上皮细胞和内皮细胞的侵袭策略和机制与肠道病原体相似。研究和阐明牙龈卟啉单胞菌等微生物在慢性感染中的持续作用机制将为牙龈卟啉单胞菌介导的牙周病的发病机制提供有价值的见解。在内皮细胞中繁殖和激活内皮细胞的能力可能是牙龈假单胞菌发挥的致病机制之一,这可能解释了最近描述的这种有机体与心血管疾病之间的联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Invasion strategies of the oral pathogen porphyromonas gingivalis: implications for cardiovascular disease.

Microorganisms have evolved a variety of mechanisms designed to evade detection and/or destruction by the host. Many pathogens evade host defenses by invading cells, thus providing the bacterium with an environment free of competing microorganisms. Adherence and invasion are active processes in which microorganisms often use host proteins and enzymes to gain entry into the cell, thus stimulating their own uptake. The investigation of invasion by the periopathogen Porphyromonas gingivalis is in its infancy in comparison with that of the enteric pathogens. However, recent studies with P. gingivalis have revealed that these organisms have developed invasion strategies and mechanisms similar to those of the enteric pathogens for both epithelial and endothelial cells. The study and elucidation of the mechanisms by which microorganisms such as P. gingivalis persist in chronic infection will provide valuable insight into the pathogenesis of P. gingivalis-mediated periodontal disease. The ability to multiply in and to activate endothelial cells may be one of the pathogenic mechanisms exerted by P. gingivalis that may explain the recently described association between this organism and cardiovascular disease.

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