Fischer 344大鼠脑乙酰胆碱酯酶分子形态活性的年龄相关性变化。

K A Skau, C G Triplett
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引用次数: 8

摘要

比较了年轻成年(6月龄)和老年(24月龄)Fischer 344大鼠6个脑区总乙酰胆碱酯酶(AChE)及其分子形态。老年纹状体(48.7%)、顶叶皮层(39%)、小脑(30.2%)和髓质/脑桥(23.1%)总AChE活性显著降低。老龄大鼠前脑乙酰胆碱酯酶(AChE)无明显减少(18.4%),而嗅球在老龄大鼠中无明显差异。在蔗糖密度梯度上分离的G4/G1分子形态的比例在所有被检查的衰老大鼠脑组织中没有改变。这些结果表明,老龄大鼠表现出脑乙酰胆碱酯酶减少,但没有证据表明其对个体分子形式有选择性影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Age-related changes in activity of Fischer 344 rat brain acetylcholinesterase molecular forms.

Total acetylcholinesterase (AChE) and the molecular forms of the enzyme from six brain regions were compared in young adult (6 mo) and aged (24 mo) Fischer 344 rats. Total AChE activity was significantly reduced in aged striatum (48.7%), parietal cortex (39%), cerebellum (30.2%), and medulla/pons (23.1%). Forebrain of aged rats showed nonsignificant reduction of AChE (18.4%), but olfactory bulbs exhibited no differences in aged rats. The ratio of G4/G1 molecular forms, as isolated on sucrose density gradients, was unaltered in all aged rat brain tissues examined. These results indicate that aged rats exhibit reduced brain AChE, but there is no evidence for selective effects on individual molecular forms.

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