[儿茶酚胺对果蝇中枢神经系统克隆细胞非递质作用的研究]。

T Zhang
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引用次数: 0

摘要

利用来源于果蝇的克隆神经细胞ML-DmBG2-c2,研究了儿茶酚胺(catecholamines, CAs)在幼虫中枢神经系统(CNS)中的作用。所有测试的儿茶酚胺,肾上腺素(AD),多巴胺(DA),去甲肾上腺素(NA)和异丙肾上腺素(ISO),在2至7天的培养中阻止细胞数量的增加。α -、β -肾上腺素能和多巴胺能拮抗剂不能阻断CAs对细胞数量的影响。肾上腺素色素,AD氧化降解的产物,也能阻止细胞数量的增加,就像AD一样。抗氧化剂二硫苏糖醇(DTT)可部分阻断AD的作用。这些结果表明,CA对细胞数量增加的抑制可能是由CA本身和/或CA代谢过程中的氧化产物介导的。结果表明,在果蝇克隆细胞中,CAs对细胞增殖有抑制作用,但不诱导细胞死亡。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Examination of non-transmitter effects of catecholamines on clonal cells derived from Drosophila CNS].

The effects of catecholamines (CAs) other than their transmitter action were investigated using clonal neuronal cells, ML-DmBG2-c2, derived from Drosophila in the larval central nervous system (CNS). All catecholamines tested, adrenaline (AD), dopamine (DA), noradrenaline (NA) and isoproterenol (ISO), prevented any increase in the number of cells during 2- to 7-day culture. alpha-, beta-adrenergic and dopaminergic antagonists did not block the effects of CAs on the number of cells. Adrenochrome, a product of the oxidative degradation of AD, also prevented any increase in the number of cells, as AD did. The effect of AD was partially blocked by an antioxidant, dithiothreitol (DTT). These results suggest that the inhibition of the increase in cell numbers by CA might be mediated by CAs themselves and/or oxidative products in the CA metabolic process. It is concluded that CAs inhibit cell proliferation but do not induce cell death in the Drosophila clonal cells.

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