{"title":"硫腙铜(II)配合物。氧化还原性质与超氧化物歧化酶模拟活性的关系","authors":"Zdena Ďuračková , Ma.Antonia Mendiola , Ma.Teresa Sevilla , Aladar Valent","doi":"10.1016/S0302-4598(98)00231-1","DOIUrl":null,"url":null,"abstract":"<div><p>The redox behaviour of copper(II) complexes with the open chain ligand, benzilbisthiosemicarbazone, and the macrocyclic one [3,4,10,11-tetraphenyl-1,2,5,8,9,12,13-octaazacyclotetradeca-7,14-dithione-2,4,9,11-tetraene] has been explored by cyclic voltammetry. The half-wave potential values for the copper(II)/copper(I) redox couple and the spectral data obtained on dimethylsulfoxide (DMSO) solution agree with the superoxide dismutase (SOD)-mimetic activity of the complexes. The macrocyclic complexes show more positive reduction potential and more activity than the open chain derivatives. From our results it follows that the structure and conformation of ligand has influence on the redox potential of central atom in coordination compound. The changes in the coordination sphere are connected with the change of biological function of compounds represented by SOD-mimic activity. In addition, the <span><math><mtext>L</mtext><msup><mi></mi><mn>1</mn></msup><mtext>H</mtext><msub><mi></mi><mn>6</mn></msub></math></span> derivatives show quasireversible waves associated to Cu(II)/Cu(III) process.</p></div>","PeriodicalId":79804,"journal":{"name":"Bioelectrochemistry and bioenergetics (Lausanne, Switzerland)","volume":"48 1","pages":"Pages 109-116"},"PeriodicalIF":0.0000,"publicationDate":"1999-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0302-4598(98)00231-1","citationCount":"32","resultStr":"{\"title\":\"Thiohydrazone copper(II) complexes. The relationship between redox properties and superoxide dismutase mimetic activity\",\"authors\":\"Zdena Ďuračková , Ma.Antonia Mendiola , Ma.Teresa Sevilla , Aladar Valent\",\"doi\":\"10.1016/S0302-4598(98)00231-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The redox behaviour of copper(II) complexes with the open chain ligand, benzilbisthiosemicarbazone, and the macrocyclic one [3,4,10,11-tetraphenyl-1,2,5,8,9,12,13-octaazacyclotetradeca-7,14-dithione-2,4,9,11-tetraene] has been explored by cyclic voltammetry. The half-wave potential values for the copper(II)/copper(I) redox couple and the spectral data obtained on dimethylsulfoxide (DMSO) solution agree with the superoxide dismutase (SOD)-mimetic activity of the complexes. The macrocyclic complexes show more positive reduction potential and more activity than the open chain derivatives. From our results it follows that the structure and conformation of ligand has influence on the redox potential of central atom in coordination compound. The changes in the coordination sphere are connected with the change of biological function of compounds represented by SOD-mimic activity. In addition, the <span><math><mtext>L</mtext><msup><mi></mi><mn>1</mn></msup><mtext>H</mtext><msub><mi></mi><mn>6</mn></msub></math></span> derivatives show quasireversible waves associated to Cu(II)/Cu(III) process.</p></div>\",\"PeriodicalId\":79804,\"journal\":{\"name\":\"Bioelectrochemistry and bioenergetics (Lausanne, Switzerland)\",\"volume\":\"48 1\",\"pages\":\"Pages 109-116\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1999-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S0302-4598(98)00231-1\",\"citationCount\":\"32\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioelectrochemistry and bioenergetics (Lausanne, Switzerland)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0302459898002311\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioelectrochemistry and bioenergetics (Lausanne, Switzerland)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0302459898002311","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Thiohydrazone copper(II) complexes. The relationship between redox properties and superoxide dismutase mimetic activity
The redox behaviour of copper(II) complexes with the open chain ligand, benzilbisthiosemicarbazone, and the macrocyclic one [3,4,10,11-tetraphenyl-1,2,5,8,9,12,13-octaazacyclotetradeca-7,14-dithione-2,4,9,11-tetraene] has been explored by cyclic voltammetry. The half-wave potential values for the copper(II)/copper(I) redox couple and the spectral data obtained on dimethylsulfoxide (DMSO) solution agree with the superoxide dismutase (SOD)-mimetic activity of the complexes. The macrocyclic complexes show more positive reduction potential and more activity than the open chain derivatives. From our results it follows that the structure and conformation of ligand has influence on the redox potential of central atom in coordination compound. The changes in the coordination sphere are connected with the change of biological function of compounds represented by SOD-mimic activity. In addition, the derivatives show quasireversible waves associated to Cu(II)/Cu(III) process.
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