胰腺腺癌患者血清新蝶呤水平。

G Manes, O A Spada, P G Rabitti, B Feola, S Misso, A Minerva, G Uomo
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引用次数: 18

摘要

结论:胰腺癌免疫系统的激活可以通过血清中新蝶呤、可溶性白细胞介素2受体(sIL-2R)和白细胞介素6 (IL-6)水平的升高来证明。这些参数的测定并不能为胰腺癌的诊断提供帮助。背景:本研究的目的是确定血清新蝶呤(巨噬细胞活性的体内标志物)在胰腺癌中的诊断价值。方法:对34例胰腺癌患者进行分析。根据UICC TNM分级,1期6例,2期9例,3期6例,4期13例。24例慢性胰腺炎患者、72例健康献血者和20例胆结石性黄疸患者作为对照组。测定各组患者血清中新蝶呤、肿瘤坏死因子(TNF)、sIL-2R、IL-6的含量;Ca 19-9在癌症和胰腺炎中也有检测。结果:肿瘤患者血清新蝶呤、sIL-2R和IL-6水平高于胰腺炎和健康供者,胰腺炎患者高于供者。三组血清TNF相似。血清neopterin、TNF、sIL-2R和IL-6水平与肿瘤分期或Ca 19-9水平无关。sIL-2R与新蝶呤水平呈正相关。梗阻性黄疸的新蝶呤水平与胰腺炎相似。Ca 19-9在推荐截止值为37 U/mL时灵敏度和特异度最高,分别为88.2和87.5%。在选择的新蝶呤截断点上,TNF、sIL-2R和IL-6在鉴别胰腺癌和胰腺炎方面的敏感性和特异性较低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neopterin serum levels in pancreatic adenocarcinoma.

Conclusions: Activation of the immune system in pancreatic cancer is demonstrated by increased serum levels of neopterin, soluble Interleukin 2 receptor (sIL-2R), and Interleukin 6 (IL-6). Determination of these parameters does not provide benefit in the diagnosis of pancreatic cancer.

Background: The aim of the study was to define the diagnostic value of serum neopterin, an in vivo marker of macrophage activity, in pancreatic cancer.

Methods: Thirty-four patients with pancreatic cancer were studied. According to the UICC TNM classification 6 were in stage I, 9 in stage II, 6 in stage III, and 13 in stage IV. Twenty-four patients with chronic pancreatitis, 72 healthy blood donors, and 20 patients with jaundice resulting from gallstones were used as control groups. Neopterin, tumor necrosis factor (TNF), sIL-2R, and IL-6 were measured in serum in the different groups; Ca 19-9 was also measured in cancer and pancreatitis.

Results: Serum levels of neopterin, sIL-2R, and IL-6 were higher in cancer than in pancreatitis and healthy donors, and in pancreatitis higher than in donors. Serum TNF was similar in the three groups. Serum levels of neopterin, TNF, sIL-2R, and IL-6 were not related to the tumor stage or to Ca 19-9 levels. A positive correlation was found between sIL-2R and neopterin levels. Neopterin levels in obstructive jaundice were similar to those of pancreatitis. Ca 19-9 at the recommended cutoff of 37 U/mL showed the best sensitivity and specificity (88.2 and 87.5%, respectively). At the selected cutoff neopterin, TNF, sIL-2R, and IL-6 showed low sensitivity and specificity in differentiating cancer from pancreatitis.

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