单克隆Gammapathies。

G Merlini, F Aguzzi, J Whicher
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引用次数: 0

摘要

血清和/或尿液中B细胞克隆产生的单克隆免疫球蛋白(单克隆成分,MC)或其亚基,重链和轻链的存在是一组称为单克隆γ病变(MG)的广泛病症的特征。在大多数情况下,MG在临床上是沉默的,并在一生中保持沉默。然而,由于其增殖(即多发性骨髓瘤及其变体)和/或MC产生器官损害(即肾衰竭,淀粉样样心肌病等),克隆可能或将在临床上变得明显。单克隆免疫球蛋白是一种理想的肿瘤标志物,临床检验员主要通过单克隆免疫球蛋白的检测和定量,为这些疾病的诊断和治疗做出了很大的贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Monoclonal gammapathies.

The presence of a serum and/or urinary monoclonal immunoglobulin (monoclonal component, MC), or its subunits, heavy and light chains produced by a B cell clone in serum and/or urine characterizes a wide group of conditions called monoclonal gammapathies (MG). In most instances, the MG is clinically silent, and remains so throughout life. However, the clone may be, or will become, clinically overt because of its proliferation (i.e., multiple myeloma and its variants) and/or because the MC produces organ damage (i.e., kidney failure, amyloidotic cardiomyopathy, etc.). The clinical laboratorian greatly contributes to the diagnosis and management of these conditions mainly through detection and quantitation of the monoclonal immunoglobulin, which represents an ideal tumor marker.

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