肠易激综合征患者的生活质量及治疗效果。

O Chassany, J F Bergmann
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引用次数: 22

摘要

背景:肠易激综合征(IBS)是普通人群的常见病。肠易激综合征症状的评估并不包括所有报告社交生活受限、需要节食和心理社会影响的患者的主诉。生活质量(QOL)测量允许对患者状态的精确方法。方法:使用通用的生活质量问卷SF 36和两个经过验证的特定生活质量问卷IBSQOL和功能性消化系统疾病FDDQL来评估IBS患者的预后。ibsql测量了9个域,并证明了其可靠性和有效性。FDDQL测量了8个域,通过与SF36比较,获得了法语、英语和德语的国际心理测量验证。对FDDQL的判别效度和反应性进行了评价。结果:在一些临床试验中,通用的生活质量评估和特定的问卷(如FDDQL)能够测量IBS患者状态和生活质量的变化。结论:特定的生活质量问卷已在IBS患者中得到验证,并可用于对照研究。肠易激综合征的治疗需要开发有效的新药,完整和准确的结果评估将涉及与特定有效问卷相关的生活质量分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Quality of life in irritable bowel syndrome, effect of therapy.

Background: Irritable bowel syndrome (IBS) is a common disease in the general population. Evaluation of IBS symptoms does not cover all the complaints of patients who report restrictions to social life, the need to diet and psychosocial repercussions. Quality of life (QOL) measurement permits a precise approach to patient status.

Methods: The generic QOL questionnaires SF 36 and two validated specific QOL questionnaires--IBSQOL and Functional Digestive Disorders FDDQL--have been used for the evaluation of IBS patient outcome. IBSQOL measures 9 domains and its reliability and validity have been demonstrated. FDDQL measures 8 domains, an international psychometric validation was obtained in French, English and German by comparison with the SF36. The discriminant validity and responsiveness of the FDDQL have been evaluated.

Results: Generic QOL evaluation and specific questionnaires like the FDDQL were able to measure changes in IBS patient status and QOL during several clinical trials.

Conclusion: Specific QOL questionnaires have been validated in IBS patients and are available for controlled studies. Development of effective new drugs are needed for IBS treatment, complete and precise evaluation of outcome will involve QOL analysis in association with specific validated questionnaires.

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