透明质酸酶侵袭组织。

Invasion & metastasis Pub Date : 1997-01-01
T B Csóka, G I Frost, R Stern, A B Csóka
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引用次数: 0

摘要

透明质酸酶是一种广泛分布的酶,具有不同的底物特异性,广泛的pH最适范围和不同的催化机制。它们可能被生物体用来互相入侵。透明质酸酶也被认为是肿瘤侵袭和转移扩散的机制。在这篇综述中,我们将更多地关注不同种类的透明质酸酶参与肿瘤转移以外的组织侵袭,介绍一些快速积累的新数据,并解决透明质酸酶及其透明质酸底物与浸润相关的悖论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hyaluronidases in tissue invasion.

Hyaluronidases are broadly distributed enzymes with varying substrate specificities, a wide range of pH optima, and different catalytic mechanisms. They may be used by organisms to invade one another. Hyaluronidases have also been invoked as mechanisms for tumor invasion and metastatic spread. In this review, we will concentrate more on the different kinds of hyaluronidases involved in tissue invasion other than cancer metastasis, present some of the rapidly accumulating new data, and address the paradox that both hyaluronidase as well as its hyaluronan substrate are associated with invasion.

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