评估乳腺癌和良性乳腺疾病患者与氧化应激的关系

Cancer biochemistry biophysics Pub Date : 1998-11-01
A Seven, Y Erbil, R Seven, F Inci, T Gülyaşar, B Barutçu, G Candan
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引用次数: 0

摘要

在这项研究中,乳腺癌(n = 23)和良性乳腺疾病(n = 15)患者被评估与氧化应激的关系。通过测定血浆中硫代巴比妥酸反应物质(TBARS)来评估脂质过氧化程度。两组乳腺癌患者红细胞谷胱甘肽过氧化物酶(GSH Px)、铜锌氧化物歧化酶(CuZn SOD)、谷胱甘肽(GSH)及血浆维生素E、胆固醇、铁、锌、铜水平均较乳腺良性疾病组显著升高(p < 0.01)、维生素E (p < 0.001)、锌(p < 0.01)、铜(p < 0.05)、胆固醇(p < 0.01), TBARS水平显著降低(p < 0.01)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Breast cancer and benign breast disease patients evaluated in relation to oxidative stress.

In this study, breast cancer (n = 23) and benign breast disease (n = 15) patients were evaluated in relation to oxidative stress. The extent of lipid peroxidation was assessed by measuring thiobarbituric acid reactive substances (TBARS) in plasma. Erythrocyte glutathione peroxidase (GSH Px), CuZn speroxide dismutase (CuZn SOD), glutathione (GSH) and plasma vitamin E, cholesterol Fe, Zn, Cu levels were analysed in both groups GSH Px (p < 0.01), vitamin E (p < 0.001), Zn (p < 0.01), Cu (p < 0.05) and cholesterol (p < 0.01) concentrations were found to be significantly increased, TBARS level (p < 0.01) significantly decreased in breast cancer patients in comparison to benign breast disease group.

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