{"title":"内啡肽介导安慰剂镇痛吗?对一篇重要论文的评论。","authors":"ter Riet G, de Craen AJ, de Boer A, Kessels","doi":"10.1159/000021069","DOIUrl":null,"url":null,"abstract":"<p><p>There are only few experimental studies that assess the hypothesis that placebo analgesia is mediated by endogenous opioids. One of these studies [Grevert P, Albert LH, Goldstein A: Partial antagonism of placebo analgesia by naloxone. Pain 1983;16:129-143] had a rather complicated design and data presentation. In this commentary we attempt to clarify the experimental design of that study. Based on a clearer understanding of the study procedures and data analysis we ropose some alternative interpretations of the results.</p>","PeriodicalId":54318,"journal":{"name":"Forschende Komplementarmedizin","volume":"5 Suppl S1 ","pages":"12-14"},"PeriodicalIF":0.0000,"publicationDate":"1998-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000021069","citationCount":"3","resultStr":"{\"title\":\"Do Endorphins Mediate Placebo Analgesia? A Critical Commentary on One of the Seminal Papers.\",\"authors\":\"ter Riet G, de Craen AJ, de Boer A, Kessels\",\"doi\":\"10.1159/000021069\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>There are only few experimental studies that assess the hypothesis that placebo analgesia is mediated by endogenous opioids. One of these studies [Grevert P, Albert LH, Goldstein A: Partial antagonism of placebo analgesia by naloxone. Pain 1983;16:129-143] had a rather complicated design and data presentation. In this commentary we attempt to clarify the experimental design of that study. Based on a clearer understanding of the study procedures and data analysis we ropose some alternative interpretations of the results.</p>\",\"PeriodicalId\":54318,\"journal\":{\"name\":\"Forschende Komplementarmedizin\",\"volume\":\"5 Suppl S1 \",\"pages\":\"12-14\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1998-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1159/000021069\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Forschende Komplementarmedizin\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1159/000021069\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Forschende Komplementarmedizin","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000021069","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 3
摘要
只有少数实验研究评估安慰剂镇痛是由内源性阿片类药物介导的假设。其中一项研究[Grevert P, Albert LH, Goldstein A:纳洛酮对安慰剂镇痛的部分拮抗作用]。[Pain, 1983; 16:29 -143]的设计和数据呈现相当复杂。在这篇评论中，我们试图澄清该研究的实验设计。基于对研究程序和数据分析的更清晰理解，我们对结果提出了一些不同的解释。
Do Endorphins Mediate Placebo Analgesia? A Critical Commentary on One of the Seminal Papers.
There are only few experimental studies that assess the hypothesis that placebo analgesia is mediated by endogenous opioids. One of these studies [Grevert P, Albert LH, Goldstein A: Partial antagonism of placebo analgesia by naloxone. Pain 1983;16:129-143] had a rather complicated design and data presentation. In this commentary we attempt to clarify the experimental design of that study. Based on a clearer understanding of the study procedures and data analysis we ropose some alternative interpretations of the results.
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