Bao-Guo Xiao , Guang-Xian Zhang, Fu-Dong Shi, Cun-Gen Ma, Hans Link
{"title":"实验性自身免疫性重症肌无力鼻耐受大鼠CD4+T细胞克隆中LFA-1的降低与TGF-β的上调相关","authors":"Bao-Guo Xiao , Guang-Xian Zhang, Fu-Dong Shi, Cun-Gen Ma, Hans Link","doi":"10.1006/clin.1998.4537","DOIUrl":null,"url":null,"abstract":"<div><p>Tolerance to experimental autoimmune myasthenia gravis by nasal administration of microgram amounts of acetylcholine receptor (AChR) has been reported. To elucidate the mechanisms behind tolerance induction via the respiratory tract and the involvement of CD4<sup>+</sup>T cells, we established AChR-specific CD4<sup>+</sup>CD8<sup>−</sup>T cell clones from nasally tolerized rats. Nasal tolerance decreased leukocyte function-associated antigen-1 (LFA-1) expression in CD4<sup>+</sup>T cells from tolerized rats. There was no difference between nasally tolerized and control rats in expression of intercellular adhesion molecule-1. The levels of transforming growth factor-β (TGF-β) mRNA-expressing cells were upregulated in CD4<sup>+</sup>T cell clones after tolerance induction. These findings suggest that decreased LFA-1 expression in CD4<sup>+</sup>T cells contributes to reduction of the infiltration of inflammatory CD4<sup>+</sup>T cells, while upregulated TGF-β may inhibit lymphocyte functions.</p></div>","PeriodicalId":10683,"journal":{"name":"Clinical immunology and immunopathology","volume":"89 3","pages":"Pages 196-204"},"PeriodicalIF":0.0000,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1006/clin.1998.4537","citationCount":"10","resultStr":"{\"title\":\"Decrease of LFA-1 Is Associated with Upregulation of TGF-β in CD4+T Cell Clones Derived from Rats Nasally Tolerized against Experimental Autoimmune Myasthenia Gravis\",\"authors\":\"Bao-Guo Xiao , Guang-Xian Zhang, Fu-Dong Shi, Cun-Gen Ma, Hans Link\",\"doi\":\"10.1006/clin.1998.4537\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Tolerance to experimental autoimmune myasthenia gravis by nasal administration of microgram amounts of acetylcholine receptor (AChR) has been reported. To elucidate the mechanisms behind tolerance induction via the respiratory tract and the involvement of CD4<sup>+</sup>T cells, we established AChR-specific CD4<sup>+</sup>CD8<sup>−</sup>T cell clones from nasally tolerized rats. Nasal tolerance decreased leukocyte function-associated antigen-1 (LFA-1) expression in CD4<sup>+</sup>T cells from tolerized rats. There was no difference between nasally tolerized and control rats in expression of intercellular adhesion molecule-1. The levels of transforming growth factor-β (TGF-β) mRNA-expressing cells were upregulated in CD4<sup>+</sup>T cell clones after tolerance induction. These findings suggest that decreased LFA-1 expression in CD4<sup>+</sup>T cells contributes to reduction of the infiltration of inflammatory CD4<sup>+</sup>T cells, while upregulated TGF-β may inhibit lymphocyte functions.</p></div>\",\"PeriodicalId\":10683,\"journal\":{\"name\":\"Clinical immunology and immunopathology\",\"volume\":\"89 3\",\"pages\":\"Pages 196-204\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1998-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1006/clin.1998.4537\",\"citationCount\":\"10\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical immunology and immunopathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0090122998945378\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical immunology and immunopathology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0090122998945378","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Decrease of LFA-1 Is Associated with Upregulation of TGF-β in CD4+T Cell Clones Derived from Rats Nasally Tolerized against Experimental Autoimmune Myasthenia Gravis
Tolerance to experimental autoimmune myasthenia gravis by nasal administration of microgram amounts of acetylcholine receptor (AChR) has been reported. To elucidate the mechanisms behind tolerance induction via the respiratory tract and the involvement of CD4+T cells, we established AChR-specific CD4+CD8−T cell clones from nasally tolerized rats. Nasal tolerance decreased leukocyte function-associated antigen-1 (LFA-1) expression in CD4+T cells from tolerized rats. There was no difference between nasally tolerized and control rats in expression of intercellular adhesion molecule-1. The levels of transforming growth factor-β (TGF-β) mRNA-expressing cells were upregulated in CD4+T cell clones after tolerance induction. These findings suggest that decreased LFA-1 expression in CD4+T cells contributes to reduction of the infiltration of inflammatory CD4+T cells, while upregulated TGF-β may inhibit lymphocyte functions.
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