糖编码在胚胎发育中的信息管理系统。

Acta anatomica Pub Date : 1998-01-01 DOI:10.1159/000046455
P L Mann, R E Waterman
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引用次数: 24

摘要

在过去的5年里,从研究胚胎发生早期阶段的实验室中出现了大量的数据。这些数据暗示了糖生物学在这些过程的启动和调控中的各个方面。来自这些调查的分析细节的水平已经超出了我们在互动/动态发展过程的背景下充分理解其总体意义的能力。这篇综述建议在对更多细节的看似无休止的追求中暂停一下,以便我们可以评估我们的目标和目的。提出的目标包括对早期胚胎发生过程中在不同“过渡点”管理的信息所涉及的过程的机制理解,以及对早期发育的空间/时间调节管理的机制的理解。发生在细胞到细胞簇、细胞簇到早期器官结构、早期器官结构到功能器官发育的“转变”是基本的,反映了生物信息管理的进化过程。所有这些“转变”都涉及到复杂性的增加,信息管理系统层次结构的发展(双向集成),以及依赖于历史事件来映射未来结构和功能的空间/时间调节。本综述侧重于相对较少的研究,这些研究突出了早期发展的这些方面。提出了一种涉及糖编码的机制,这是罗斯曼假说的延伸,它直接用作信息管理系统,并提出了一些支持的实验证据。现有假设的延伸与最近的几项研究有关,旨在拓宽未来研究的实验设计,以便解决这些重要的过程问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Glycocoding as an information management system in embryonic development.

The past 5 years have seen a burgeoning in the amount of data emerging from laboratories studying the early stages of embryogenesis. Much of this data implicates various aspects of glycobiology in the initiation and regulation of these processes. The level of analytical detail coming from these investigations has surpassed our ability to fully understand its overall significance within the context of the interactive/dynamic developmental process. This review proposes a pause in this seemingly endless quest for more detail so that we may take stock of our goals and objectives. The proposed goals include a mechanistic understanding of the process(es) involved in information managed at various 'transition points' during early embryogenesis, and an understanding of the mechanism(s) by which the spatial/temporal regulation of early development are managed. The 'transitions' which occur during cell to cell cluster, cell cluster to early organ architecture, and early organ architecture to functional organ development are fundamental and mirror the evolutionary process of biological information management. All of these 'transitions' involve increasing complexity, the development of hierarchies of information management systems (integrated bidirectionally), and spatial/temporal regulation which relies on historical events to map future structure and function. This review focuses on a relatively small number of studies which highlight these aspects of early development. A mechanism which involves glycocoding, an extension of the Roseman Hypothesis, and its direct use as an information management system is proposed and some supporting experimental evidence is presented. This extension of an existing hypothesis is related to several recent investigations, and is designed to broaden the experimental design of future studies so that these important process issues can be addressed.

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