[台湾不同地区分离的金黄色葡萄球菌凝固酶类型及药敏分析]。

S E Hsieh, J L Liu
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引用次数: 0

摘要

对1992年2月~ 1993年12月台湾地区临床分离的129株金黄色葡萄球菌,采用Pasco MIC革兰氏阳性试剂盒进行凝固酶分型和21种抗菌药物的药敏试验。在最小抑制浓度(MIC)测定中,对青霉素和氨苄西林耐药94株(72.9%),对四环素和红霉素耐药54株(41.9%),对oxacillin耐药21株(16.3%);ORSA),但对万古霉素和呋喃妥因均无耐药。对4个不同地区的分离株进行药敏比较,除台湾南部地区对青霉素和氨苄西林耐药率较高,中部地区对利福平和庆大霉素耐药率较高外,无统计学差异。ORSA菌株对青霉素、氨苄西林、四环素均耐药;95.2%的菌株对庆大霉素、妥布霉素和红霉素耐药。除万古霉素、呋喃妥英、甲氧苄啶/磺胺甲恶唑和氨苄西林/舒巴坦外,ORSA菌株的耐药率均高于OSSA菌株。在127株凝固酶分型中,以IV型、III型和VII型最为常见。在凝血酶类型中,ⅳ型在台湾北部、南部和东部多见;第三型主要发生在台湾中部。在ORSA菌株中,凝固酶III型以85%的比例最高。总之,抗生素谱的分析很容易进行,结果不仅可以为临床医生提供正确的患者治疗指导,而且还可以为流行病学研究提供有用的工具。然而,如果同时进行抗生素谱和凝血酶分型,结果将更可靠的流行病学研究,包括医院感染调查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Coagulase type and antimicrobial susceptibility of Staphylococcus aureus isolated from various areas in Taiwan].

A total of 129 strains of Staphylococcus aureus, isolated from clinical specimens in Taiwan between February 1992 and December 1993, were subjected to coagulase typing and susceptibility testing to 21 kinds of antimicrobial agents using Pasco MIC Gram-positive panels. In the determination of minimum inhibition concentration (MIC), there were 94 strains (72.9%) resistant to penicillin and ampicillin, 54 strains (41.9%) resistant to tetracycline and erythromycin, and 21 strains (16.3%) resistant to oxacillin (oxacillin-resistant S. aureus; ORSA), but none of them was resistant to vancomycin or nitrofurantoin. As the susceptibility of the isolates from four different geographic districts was compared, no statistical difference was found except that the resistance rate to penicillin and ampicillin was higher in southern Taiwan, and resistance rate to rifampin and gentamicin was higher in central Taiwan. The ORSA strains were all resistant to penicillin, ampicillin, tetracycline; 95.2% of the strains were resistant to gentamicin, tobramycin and erythromycin. The resistance rates to drugs tested for ORSA strains were statistically higher than those for OSSA strains except vancomycin, nitrofurantoin, trimethoprim/sulfamethoxazole and ampicillin/sulbactam. In the coagulase typing of 127 strains, Type IV, III and VII were most frequently encountered. Among the coagulase types, Type IV was mostly encountered in the North, the South and the East of Taiwan; Type III was mostly encountered in central Taiwan. Among the ORSA strains, coagulase Type III was most predominant (85%). In conclusion, analysis of an antibiogram is easy to perform and the results can provide clinicians not only with correct guides for patient treatment but also with a useful tool for epidemiological studies. However, if antibiogram and coagulase typing are carried out simultaneously, results will be more reliable in epidemiological studies, including nosocomial infection survey.

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