使用立体定向伴随剂量递增的恶性胶质瘤加速放疗方案。

R M Cardinale, R K Schmidt-Ullrich, S H Benedict, R D Zwicker, D C Han, W C Broaddus
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引用次数: 32

摘要

本初步研究的目的是确定加速治疗方案的可行性和毒性,通过在标准外束照射(EBXRT)过程中每周给予立体定向放疗增强治疗恶性胶质瘤患者。12名患者接受了恶性胶质瘤活检或次全切除,并参加了该方案,该方案提供44 Gy- ebxrt和12 Gy立体定向放疗,连续3周治疗,总剂量为80 Gy,持续33天。3例间变性星形细胞瘤患者和9例多形性胶质母细胞瘤患者的中位生存时间分别为33个月和16个月。所有肿瘤复发均在高剂量照射区域内或附近。没有患者需要中断治疗,也没有出现急性并发症。2例患者在随访期间出现癫痫发作,4例患者在第二次手术时被诊断为放射性坏死。该治疗方案可行且耐受性良好,其后期并发症发生率与放射手术或间质性近距离放疗相似。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Accelerated radiotherapy regimen for malignant gliomas using stereotactic concomitant boosts for dose escalation.

The purpose of this pilot study was to determine the feasibility and toxicities of an accelerated treatment program by using a concomitant stereotactic radiotherapy boost given weekly during a course of standard external-beam irradiation (EBXRT) in patients with malignant gliomas. Twelve patients underwent biopsy or subtotal resection of a malignant glioma and were enrolled on the protocol, which delivered 44 Gy-EBXRT and a 12-Gy stereotactic radiotherapy boost given on 3 consecutive weeks of treatment for a total dose of 80 Gy over 33 days. Three patients with anaplastic astrocytoma and nine patients with glioblastoma multiforme had median survival times of 33 months and 16 months, respectively. All of the tumor recurrences were within or were closely adjacent to the region of high-dose irradiation. None of the patients required a treatment break, and there were no acute complications. Two patients developed seizures in the follow-up period, and four patients were diagnosed with radionecrosis at the time of the second operation. The treatment program was found to be feasible and was well tolerated, and it resulted in a rate of late complications similar to those of radiosurgery or interstitial brachytherapy.

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