Maja Krajinovic , Chantal Richer , Ljiljana Lukovic , Damian Labuda , Daniel Sinnett
{"title":"辐射杂交作图对复制错误易感位点的染色体分配","authors":"Maja Krajinovic , Chantal Richer , Ljiljana Lukovic , Damian Labuda , Daniel Sinnett","doi":"10.1016/S1383-5726(97)00015-0","DOIUrl":null,"url":null,"abstract":"<div><p>Genetic instability due to a DNA mismatch repair<span><span> deficiency leads to the replication error (RER) phenotype in cancer cells. Certain loci are more susceptible to replication errors than the genomic average. The mapping of such loci is important, because it could indicate chromosomal domains preferentially affected by RER. Here, we report the radiation hybrid mapping of five markers known to be highly sensitive to RER in </span>carcinomas. They were localized in chromosomes 2q34–q36.1, 6p24.3–25.2, 7q22.1–q13.2, 16q23.2–q23.3 and Xq13.1–q21.2 near genes that could be involved in oncogenesis.</span></p></div>","PeriodicalId":100939,"journal":{"name":"Mutation Research/Mutation Research Genomics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1998-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1383-5726(97)00015-0","citationCount":"4","resultStr":"{\"title\":\"Chromosomal assignment of loci susceptible to replication errors by radiation hybrid mapping\",\"authors\":\"Maja Krajinovic , Chantal Richer , Ljiljana Lukovic , Damian Labuda , Daniel Sinnett\",\"doi\":\"10.1016/S1383-5726(97)00015-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Genetic instability due to a DNA mismatch repair<span><span> deficiency leads to the replication error (RER) phenotype in cancer cells. Certain loci are more susceptible to replication errors than the genomic average. The mapping of such loci is important, because it could indicate chromosomal domains preferentially affected by RER. Here, we report the radiation hybrid mapping of five markers known to be highly sensitive to RER in </span>carcinomas. They were localized in chromosomes 2q34–q36.1, 6p24.3–25.2, 7q22.1–q13.2, 16q23.2–q23.3 and Xq13.1–q21.2 near genes that could be involved in oncogenesis.</span></p></div>\",\"PeriodicalId\":100939,\"journal\":{\"name\":\"Mutation Research/Mutation Research Genomics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1998-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S1383-5726(97)00015-0\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mutation Research/Mutation Research Genomics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1383572697000150\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mutation Research/Mutation Research Genomics","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1383572697000150","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Chromosomal assignment of loci susceptible to replication errors by radiation hybrid mapping
Genetic instability due to a DNA mismatch repair deficiency leads to the replication error (RER) phenotype in cancer cells. Certain loci are more susceptible to replication errors than the genomic average. The mapping of such loci is important, because it could indicate chromosomal domains preferentially affected by RER. Here, we report the radiation hybrid mapping of five markers known to be highly sensitive to RER in carcinomas. They were localized in chromosomes 2q34–q36.1, 6p24.3–25.2, 7q22.1–q13.2, 16q23.2–q23.3 and Xq13.1–q21.2 near genes that could be involved in oncogenesis.
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