间皮瘤膜性染色的评价。

J A King, J A Tucker
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引用次数: 0

摘要

免疫组化标记常用于帮助分类累及胸膜的恶性肿瘤。虽然上皮膜抗原(EMA)和人乳脂球-2 (HMFG-2)分别被报道染色大多数腺癌和间皮瘤病例,作者已经报道,这两种抗体的染色模式可以是一个有用的鉴别。两者均表现为间皮瘤的膜性染色和腺癌的细胞质染色。对23例恶性间皮瘤和22例腺癌进行免疫染色。对于EMA, 78%的间皮瘤和86%的腺癌呈阳性染色,65%的间皮瘤和14%的腺癌呈膜性染色模式。对于HMFG-2, 9%的间皮瘤和50%的腺癌呈阳性染色,4%的间皮瘤和9%的腺癌呈膜样染色。HMFG-2的膜染色不是一个有用的标准。在这个系列中,EMA的膜性染色模式识别恶性间皮瘤的敏感性为65%,特异性为86%。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of membranous staining of mesothelioma.

Panels of immunohistochemical markers are often used to aid in categorizing malignant neoplasms involving the pleura. While epithelial membrane antigen (EMA) and human milk fat globule-2 (HMFG-2) are each reported to stain the majority of cases of adenocarcinoma and mesothelioma, authors have reported that the pattern of staining for these two antibodies can be a useful discriminant. Both are described as revealing a membranous pattern of staining for mesothelioma and a cytoplasmic staining pattern in adenocarcinoma. Immunostains were performed on 23 cases of malignant mesothelioma and 22 cases of adenocarcinoma. For EMA, 78% of mesotheliomas and 86% of adenocarcinomas stained positively, and 65% of mesotheliomas vs. 14% of adenocarcinomas exhibited a membranous staining pattern. For HMFG-2, 9% of mesotheliomas and 50% of adenocarcinomas stained positively, and 4% of mesotheliomas vs. 9% of adenocarcinomas exhibited a membranous staining pattern. Membranous staining for HMFG-2 was not a useful criterion. In this series, a membranous pattern of staining for EMA had a sensitivity of 65% and a specificity of 86% for the identification of malignant mesothelioma.

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