脑内细胞器Ca2+泵的分布和异构体多样性。

F Baba-Aissa, L Raeymaekers, F Wuytack, L Dode, R Casteels
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引用次数: 82

摘要

细胞器型Ca2+转运atp酶的基因家族由三个成员组成。SERCA1仅在快速骨骼肌中表达;SERCA2是普遍表达的,而SERCA3被认为主要表达在造血细胞和一些上皮细胞中。在大脑中,细胞器型Ca2+转运atp酶几乎完全由SERCA2基因转录。已经描述了四种不同的SERCA2 mrna(1-4类)。然而,与表达1类、2类和3类剪接变体的非神经元细胞不同,大脑中主要的SERCA2 mRNA是4类信使。与第2类和第3类类似,第4类编码普遍表达的SERCA2b蛋白。最近,我们报道了SERCA亚型在大脑中的分布(Baba-Aissa et al., 1996a,b)。SERCA2b存在于所有研究脑区的大多数神经元中。在小脑的浦肯野神经元和海马体的锥体细胞中发现了最高的水平。有趣的是,SERCA3和SERCA2a在浦肯野神经元中与SERCA2b一起共表达,但如果存在的话,在其他大脑区域中表达较弱。由于这三种蛋白质异构体对Ca2+具有不同的亲和力,因此讨论了它们在神经元中与Ca2+储存相关的可能作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Distribution and isoform diversity of the organellar Ca2+ pumps in the brain.

The gene family of organellar-type Ca2+ transport ATPases consists of three members. SERCA1 is expressed exclusively in fast skeletal muscle; SERCA2 is ubiquitously expressed, whereas SERCA3 is considered to be mainly expressed in cells of the hematopoietic lineage and in some epithelial cells. In the brain, the organellar-type Ca2+ transport ATPases are almost exclusively transcribed from the SERCA2 gene. Four different SERCA2 mRNAs have been described (classes 1-4). However, unlike in nonneuronal cells, which express the class 1, 2, and 3 splice variants, the main SERCA2 mRNA in the brain is the class 4 messenger. Similar to classes 2 and 3, the class 4 codes for the ubiquitously expressed SERCA2b protein. Recently, we have reported the distribution of the SERCA isoforms in the brain (Baba-Aissa et al., 1996a,b). SERCA2b was present in most neurons of all investigated brain regions. The highest levels were found in the Purkinje neurons of the cerebellum and in the pyramidal cells of the hippocampus. Interestingly, SERCA3 and SERCA2a are coexpressed along with SERCA2b in the Purkinje neurons, but are weakly expressed in the other brain regions if present at all. Since these three protein isoforms have a different affinity for Ca2+, their possible roles in relation to Ca2+ stores in neurons are discussed.

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