帕金森病的ECT治疗。运动症状、单胺代谢物和神经肽的变化。

P A Fall, R Ekman, A K Granérus, L H Thorell, J Wålinder
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引用次数: 44

摘要

对16例无抑郁、无痴呆的晚期帕金森病患者进行电休克治疗。在所有患者中都观察到抗帕金森效应,1例患者持续18个月,7例患者持续3-5个月,8例患者持续几天至四周。电休克后脑脊液中高香草酸和神经肽Y水平明显升高。与短期持续改善组相比,8例ECT后持久运动改善的患者csf -3-甲氧基-4-羟基苯乙二醇显著降低。5例患者在电痉挛治疗后出现短暂性精神错乱。在这些患者中,没有其他患者,在ECT治疗前已经发现了高白蛋白比率——这是血液CSF屏障损伤的一个迹象。我们的研究结果表明ECT对于难治性PD或对抗帕金森药物不耐受的PD患者是有价值的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ECT in Parkinson's disease. Changes in motor symptoms, monoamine metabolites and neuropeptides.

Electroconvulsive therapy (ECT) was given to 16 non-depressed, non-demented patients with advanced Parkinson's disease (PD). In all the patients an antiparkinsonian effect was seen, lasting for 18 months in one patient, 3-5 months in seven patients, and a few days to four weeks in eight patients. After ECT the levels of homovanillic acid and neuropeptide Y in cerebrospinal fluid (CSF) were significantly increased. The eight patients with long lasting motor improvement after ECT had significantly lower CSF-3-methoxy-4-hydroxyphenylglycol compared to the group with short lasting improvement. Five patients developed transitory mental confusion after ECT. In these patients, and in no others, a high albumin-ratio was found already before ECT was given - an indication of blood CSF barrier damage. Our results suggest that ECT is valuable in patients with drug refractory PD or PD with intolerance to antiparkinsonian drugs.

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