人类ras- gap - sh3结构域结合蛋白的小鼠同源物鉴定和结构确认,这些蛋白含有RNA识别基序。

D Kennedy, S A Wood, T Ramsdale, P P Tam, K A Steiner, J S Mattick
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引用次数: 0

摘要

人ras- gtpase激活蛋白(GAP120) SH3结构域结合蛋白(G3BP)是近年来发现的一种特异性结合GAP120 SH3结合结构域的蛋白。在这里,我们报道了小鼠G3BP cDNA的鉴定,并通过三维建模确认了编码蛋白中的RNA识别基序(RRM)。小鼠G3BP还包含一个RGG结构域、一个富酸氨基酸结构域和几个SH3结构域结合的共识序列,表明哺乳动物G3BP代表了一个新的信号转导蛋白家族,将酪氨酸激酶连接受体与细胞RNA代谢联系起来。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Identification of a mouse orthologue of the human ras-GAP-SH3-domain binding protein and structural confirmation that these proteins contain an RNA recognition motif.

Human ras-GTPase-activating protein (GAP120) SH3-domain-binding protein (G3BP) has recently been identified on the basis of its specific binding to the GAP120 SH3 binding domain. Here we report the identification of a mouse G3BP cDNA and the confirmation by three dimensional modelling of an RNA recognition motif (RRM) in the encoded protein. Mouse G3BP also contains an RGG domain, an acid-rich amino acid domain, and several SH3 domain-binding consensus sequences, indicating that mammalian G3BPs represent a new family of signal transduction proteins which connect tyrosine kinase-linked receptors to cellular RNA metabolism.

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