多巴胺受体对低氧通气反应的影响。

Nihon Kyobu Shikkan Gakkai zasshi Pub Date : 1997-12-01
S Osanai, Y Akiba, H Matsumoto, H Nakano, K Kikuchi
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引用次数: 0

摘要

研究了静脉注射多巴胺(DA)激动剂和拮抗剂对麻醉、迷走神经切断和机械通气兔膈神经缺氧反应的影响。实验在完整和颈动脉窦去神经动物中进行。在正常动物中,缺氧刺激(FIO2 = 0.10)增加了综合膈神经活动(iPNA)的幅度,但没有改变呼吸频率。在颈动脉窦失神经动物中,缺氧逐渐降低iPNA。DA拮抗剂氟哌啶醇(0.5mg/kg,静脉滴注)和DA激动剂阿波啡(0.3mg/kg,静脉滴注)均未改变正常缺氧时完整或去神经组的iPNA。氟哌啶醇可增强完整组iPNA对缺氧的反应。阿波啡降低了对iPNA的缺氧反应。虽然阿波啡没有改变去神经组对iPNA的对照缺氧反应,但氟哌啶醇增强了颈动脉窦去神经组的缺氧呼吸抑制。因此,我们得出结论,DA对外周化学感受器的作用抑制了缺氧通气反应,但刺激了中枢神经系统的缺氧通气反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Effect of dopamine receptor on hypoxic ventilatory response].

We studied the effect of intravenous administration of a dopamine (DA) agonist and antagonist on the hypoxic response of phrenic nerve activity in anesthetized, vagotomized and mechanically ventilated rabbits. The experiments were performed in both intact and carotid sinus denervated animals. In the intact animals, hypoxic challenge (FIO2 = 0.10) increased the amplitude of integrated phrenic nerve activity (iPNA) without any alteration in respiratory frequency. In the carotid sinus denervated animals, the hypoxia progressively depressed iPNA. Neither the DA antagonist, haloperidol (0.5mg/kg i.v.), nor the DA agonist, apomorphine (0.3mg/kg, i.v.) changed the iPNA during normoxia in either the intact or denervated group. Administration of haloperidol enhanced iPNA response to hypoxia in the intact group. Apomorphine decreased the hypoxic response to iPNA. Although apomorphine did not change the control hypoxic response to iPNA in the denervated group, haloperidol augmented hypoxic respiratory depression in the carotid sinus denervated group. Therefore, we concluded that the effect of DA on peripheral chemoreceptors inhibits the hypoxic ventilatory response, but stimulates the hypoxic ventilatory response in the central nervous system.

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