细菌赖氨酸生物合成的酶学。

G Scapin, J S Blanchard
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引用次数: 110

摘要

细菌已经进化出三种从天冬氨酸合成赖氨酸的策略,通过形成中间二氨基苯甲酸(DAP),一种代谢产物,也参与肽聚糖的形成。本章的目的是描述二氢二吡啶酸合成酶、二氢二吡啶酸还原酶、四氢二吡啶酸n -琥珀基转移酶、n -琥珀基-L、L-DAP转氨酶、n -琥珀基-L、L-DAP去琥珀基酶、L、L-DAP外酯酶、L、L-DAP脱羧酶和DAP脱氢酶催化反应的机理研究。这些酶在动力学、同位素和x射线晶体学数据方面进行了讨论,这些数据允许人们推断这些酶与其底物、辅酶和抑制剂相互作用的性质。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Enzymology of bacterial lysine biosynthesis.

Bacteria have evolved three strategies for the synthesis of lysine from aspartate via formation of the intermediate diaminopimelate (DAP), a metabolite that is also involved in peptidoglycan formation. The objectives of this chapter are descriptions of mechanistic studies on the reactions catalyzed by dihydrodipicolinate synthase, dihydrodopicolinate reductase, tetrahydrodipicolinate N-succinyl-transferase, N-succinyl-L,L-DAP aminotransferase, N-succinyl-L,L-DAP desuccinylase, L,L-DAP epimerase, L,L-DAP decarboxylase, and DAP dehydrogenase. These enzymes are discussed in terms of kinetic, isotopic, and X-ray crystallographic data that allow one to infer the nature of interactions of each of these enzymes with its substrate(s), coenzymes, and inhibitors.

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