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引用次数: 37
摘要
巯基酸是S-(n -乙酰基)- l -半胱氨酸的缀合物，在外源性药物解毒和内源性药物如雌激素和白三烯的代谢过程中形成。许多汞化物是由相应的谷胱甘肽s缀合物形成的。本章着重于(a)半胱氨酸s缀合β -裂解酶的发现;(b)吡哆醛-5-磷酸的参与;(c)与硫原子相连的基团的吸电子性质的影响;(d)半胱氨酸s缀合物作为前药的潜力。
Mercapturic acids are conjugates of S-(N-acetyl)-L-cysteine formed during the detoxification of xenobiotics and during the metabolism of such endogenous agents as estrogens and leukotrienes. Many mercaturates are formed from the corresponding glutathione S-conjugates. This chapter focuses on (a) the discovery of the cysteine S-conjugate beta-lyases; (b) the involvement of pyridoxal-5-phosphate; (c) the influence of the electron-withdrawing properties of the group attached to the sulfur atom; and (d) the potential of cysteine S-conjugates as pro-drugs.
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