利用谷氨酰胺作为酰胺供体的酶。

H Zalkin, J L Smith
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引用次数: 256

摘要

来自谷氨酰胺的酰胺氮是氮原子的主要来源,可以通过生物合成的方式结合到其他氨基酸、嘌呤和嘧啶碱基、氨基糖和辅酶中。一个由至少16个氨基转移酶组成的家族已知催化酰胺氮从谷氨酰胺转移到它们的受体底物。最近精细结构的进展,主要是由于x射线晶体学,现在提供了基于结构的机制,有助于解释几种转氨酶的催化和调节相互作用的基本方面。本章综述了氨基转移酶的结构和机制表征的最新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Enzymes utilizing glutamine as an amide donor.

Amide nitrogen from glutamine is a major source of nitrogen atoms incorporated biosynthetically into other amino acids, purine and pyrimidine bases, amino-sugars, and coenzymes. A family comprised of at least sixteen amidotransferases are known to catalyze amide nitrogen transfer from glutamine to their acceptor substrates. Recent fine structural advances, largely as a result of X-ray crystallography, now provide structure-based mechanisms that help to explain fundamental aspects of the catalytic and regulatory interactions of several of these aminotransferases. This chapter provides an overview of this recent progress made on the characterization of amidotransferase structure and mechanism.

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