血红蛋白变异时HbA1c的测定:三种HPLC技术的比较。

European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies Pub Date : 1997-12-01

M Carta, G Dall'Olio, G Soffiati

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引用次数: 0

摘要

Hb变异的存在可能会导致目前在意大利实验室使用的HPLC技术测量的HbA1c值的分析干扰。在本研究中，比较了一种新型高效液相色谱体系(HA-8140, Menarini)和两种传统高效液相色谱体系(HA-8121, Menarini和Diamat, Bio-Rad)。HA-8140系统检测Hb变异可能存在于一个独立的峰中。在计算HbA1c百分比值时，不计算该峰的积分面积。这样就避免了用传统HPLC系统得到的值的低估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Determination of HbA1c in the presence of haemoglobin variants: comparison of three HPLC techniques.

The presence of Hb variants may cause analytical interference in HbA1c values measured with the HPLC techniques currently used in Italian laboratories. In this study performance of a new HPLC system, (HA-8140, Menarini) was compared with two other traditional HPLC systems (HA-8121, Menarini and Diamat, Bio-Rad). The HA-8140 system detects the Hb variant possibly present in an independent peak. The integration area of such a peak is not computed in the calculation of the percentage value of HbA1c. In this manner the underestimation of values obtained with traditional HPLC systems is avoided.

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European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies

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