{"title":"S-100蛋白在三甲基锡诱导的大鼠海马神经变性中的表达。免疫化学和免疫细胞化学研究。","authors":"P Vinesi, M C Geloso, F Michetti","doi":"10.1007/BF02815172","DOIUrl":null,"url":null,"abstract":"<p><p>After acute trimethyltin (TMT) intoxication (21 d after a single i.p. injection at a dose of 8 mg/kg) the histological, immunohistochemical, and immunochemical investigation of adult rat hippocampus showed a distinct pattern of neuronal loss, and an increase in both glial fibrillary acidic protein- (GFAP) immunoreactive cells and GFAP concentration, as expected. S-100-immunoreactive cells also increased markedly, whereas the concentration of S-100 increased even more than that of GFAP. The data show that S-100 is an index of glial reaction to damage after TMT intoxication and suggest the potential usefulness of exploring the possibility that it may play a role in induced neurodegenerative processes.</p>","PeriodicalId":18736,"journal":{"name":"Molecular and chemical neuropathology","volume":"32 1-3","pages":"129-41"},"PeriodicalIF":0.0000,"publicationDate":"1997-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02815172","citationCount":"9","resultStr":"{\"title\":\"S-100 proteins in trimethyltin-induced neurodegeneration in the rat hippocampus. An immunochemical and immunocytochemical study.\",\"authors\":\"P Vinesi, M C Geloso, F Michetti\",\"doi\":\"10.1007/BF02815172\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>After acute trimethyltin (TMT) intoxication (21 d after a single i.p. injection at a dose of 8 mg/kg) the histological, immunohistochemical, and immunochemical investigation of adult rat hippocampus showed a distinct pattern of neuronal loss, and an increase in both glial fibrillary acidic protein- (GFAP) immunoreactive cells and GFAP concentration, as expected. S-100-immunoreactive cells also increased markedly, whereas the concentration of S-100 increased even more than that of GFAP. The data show that S-100 is an index of glial reaction to damage after TMT intoxication and suggest the potential usefulness of exploring the possibility that it may play a role in induced neurodegenerative processes.</p>\",\"PeriodicalId\":18736,\"journal\":{\"name\":\"Molecular and chemical neuropathology\",\"volume\":\"32 1-3\",\"pages\":\"129-41\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1997-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/BF02815172\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular and chemical neuropathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/BF02815172\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular and chemical neuropathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/BF02815172","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
S-100 proteins in trimethyltin-induced neurodegeneration in the rat hippocampus. An immunochemical and immunocytochemical study.
After acute trimethyltin (TMT) intoxication (21 d after a single i.p. injection at a dose of 8 mg/kg) the histological, immunohistochemical, and immunochemical investigation of adult rat hippocampus showed a distinct pattern of neuronal loss, and an increase in both glial fibrillary acidic protein- (GFAP) immunoreactive cells and GFAP concentration, as expected. S-100-immunoreactive cells also increased markedly, whereas the concentration of S-100 increased even more than that of GFAP. The data show that S-100 is an index of glial reaction to damage after TMT intoxication and suggest the potential usefulness of exploring the possibility that it may play a role in induced neurodegenerative processes.