Walter E. Kaufmann , Katrin I. Andreasson , Peter C. Isakson , Paul F. Worley
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引用次数: 262
摘要
前列腺素(pg)是Samuelsson在30多年前首次在大脑中描述的(Samuelsson, 1964)。从那时起，大量的研究表明，pg是在大脑和脊髓的某些区域形成的，是对各种刺激的反应。最近鉴定的两种形式的环加氧酶(COX;Kujubu et al.， 1991;谢等，1991;Smith和DeWitt, 1996)，这两种基因都在大脑中表达，以及绘制COX分布的优越工具，促使人们对pg在中枢神经系统(CNS)中的作用重新产生兴趣。在这篇综述中，我们将描述这一领域的新数据，重点关注COX亚型在脑功能和疾病中的分布和潜在作用。
Prostaglandins (PGs) were first described in the brain by Samuelsson over 30 years ago (Samuelsson, 1964). Since then a large number of studies have shown that PGs are formed in regions of the brain and spinal cord in response to a variety of stimuli. The recent identification of two forms of cyclooxygenase (COX; Kujubu et al., 1991; Xie et al., 1991; Smith and DeWitt, 1996), both of which are expressed in the brain, along with superior tools for mapping COX distribution, has spurred a resurgence of interest in the role of PGs in the central nervous system (CNS). In this review we will describe new data in this area, focusing on the distribution and potential role of the COX isoforms in brain function and disease.
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